心脏停跳期间气道持续正压对肺顺应性的影响  

The effects of different continuous positive airway pressure on lung compliance during cardiac arrest in rats

作　　者：郭长春[1] 耿英杰[1] 李文志[1] 郑方[1] 

机构地区：[1]哈尔滨医科大学附属第二医院麻醉科

出　　处：《中国急救医学》1999年第5期262-264,共3页Chinese Journal of Critical Care Medicine

摘　　要：目的探讨不同的气道持续正压对大鼠心脏停跳期间静态胸廓—肺顺应性（ＳＴＬＣ）的影响。方法将２８只Ｗｉｓｔａｒ大白鼠随机分为４组，Ｐ０组（ｎ＝７）：不施加持续气道正压；Ｐ５组（ｎ＝７）：施加５ｃｍＨ２Ｏ的持续气道正压；Ｐ１０组（ｎ＝７）：施加１０ｃｍＨ２Ｏ的持续气道正压；Ｐ１５组：施加１５ｃｍＨ２Ｏ的持续气道正压，气道内加压前及气道内加压后的３０分钟、６０分钟、９０分钟及１２０分钟分别测量ＳＴＬＣ。结果气道内加压前各组间的ＳＴＬＣ无显著差异（Ｐ＞００５），但在加压３０分钟、６０分钟、９０分钟及１２０分钟后均明显低于加压前的值（Ｐ＜００５），而以Ｐ５及Ｐ１５组的下降最为明显。加压６０分钟后，Ｐ１０组的ＳＴＬＣ明显高于Ｐ５、Ｐ１５组（Ｐ＜００５）。加压后１２０分钟，不但Ｐ１０组的ＳＴＬＣ明显高于Ｐ１５及Ｐ５组，Ｐ０组也明显高于Ｐ１５及Ｐ５组（Ｐ＜００５）。在整个观察期间Ｐ１０组与Ｐ０组间无明显差异，同时Ｐ５组与Ｐ１５组间也无显著差异（Ｐ＞００５）。结论气道内加压１０ｃｍＨ２Ｏ可预防静态胸廓—肺顺应性的显著下降。Objective To study the effects of different continuous positive airway pressure (CPAP) on static thoracic wall-lung compliance (STLC) during cardiac arrest in rats. Method Twenty-eight Wistar rats were randomly divided into four groups,P0(n=7):without CPAP(no airway pressure was added);P5(n=7):with 5 cmH2O CPAP;P10(n=7):with 10cm H2O CPAP;P15(n=7):with 15cmH2O CPAP.The STLC was measured 30min60min90min120 min after giving CPAP. ResultsThere were no significant differences in STLC among four groups before giving CPAP(P>005).But the values of STLC reduced obviously after giving CPAP than that of no CPAP(P<005),Especially that in group P10 and group P5 and P15 at 60 min after giving CPAP(P<005).Not only the STLC of group P10 was more higher than that of group P15 and group P5,but also the STLC of group P0 at 120 min after giving CPAP.There was no singificant difference between group P10 and group P0,group P5 and group P15 in the period of whole investigation.HZConclusion Giving 10 cmH2O CPAP plays an effective role in preventing STLC from reducing obviously.

关 键 词：静态胸廓 肺顺应性 气道持续正压 心脏停跳 

分 类 号：R541.78[医药卫生—心血管疾病] R459.6[医药卫生—内科学]