生物激活磁共振成像造影剂的研究进展  

Recent Progress in Development of Bio-Active MRI Contrast Agents

作　　者：俞开潮[1,2] 吕志勇[1] 姚遥[1] 付世涛[1] 丁尚武[2] 周锦兰[1] 

机构地区：[1]华中科技大学化学与化工学院,湖北武汉430074 [2]中山大学化学系,台湾高雄80424

出　　处：《波谱学杂志》2010年第3期355-368,共14页Chinese Journal of Magnetic Resonance

基　　金：国家自然科学基金资助项目(20675033;20672039);台湾国科会"大学追求卓越计划"资助项目(95-2752-M-110-014PAE)

摘　　要：介绍了磁共振成像新一代造影剂——生物激活造影剂(亦称之为"酶激活"、"生物应答"或"智能型"造影剂)的研究进展.主要讲述了这类造影剂的设计原理、性能与作用.它们主要分别对生物体内的酶、金属离子浓度、pH等敏感.Bio-activated MRI contrast agents are often called ＂enzyme activated＂,＂bio-responsive＂ or ＂smart＂ contrast agents because they respond,specifically,to enzymatic activity,metal ion concentration,pH et al factors,respectively.Recent progress in the development of bio-activated MRI contrast agents is reviewed with the emphasis on the design principle of contrast generation based on the analysis of the structure,properties and functions of these compounds.

关 键 词：磁共振成像 造影剂 生物敏感 

分 类 号：O657.2[理学—分析化学]