硫普罗宁注射剂安全性再评价  

Safety Reevaluation of Tiopronin Injection

作　　者：洪花[1] 赵相任[2] 李志满[1] 

机构地区：[1]吉林大学实验动物中心,长春130021 [2]吉林大学口腔医学院,长春130041

出　　处：《实验动物科学》2010年第4期55-58,共4页Laboratory Animal Science

基　　金：吉林省科技发展计划资助项目(编号:20082124)

摘　　要：目的针对上市硫普罗宁注射剂存在一定临床反应的反馈,对市售硫普罗宁注射剂进行安全性再评价。方法对硫普罗宁注射剂进行血管刺激性、溶血性、过敏性试验。人与动物剂量换算依照1:20(家兔和豚鼠)。结果硫普罗宁注射剂对家兔耳缘静脉无明显刺激作用;对家兔红细胞无明显溶血及致凝聚作用;对豚鼠无过敏作用。结论上市硫普罗宁注射剂供临床静脉注射用安全性尚好。Objective Reevaluate the safety of soled tiopronin injection according to the feedback of its existing certain clinical reaction.Method Make an experiment of tiopronin injection on vascular stimulation,hemolysis,and sensitization.The dosage conversion between people and animals is 1∶ 20（rabbits and guinea pigs）.Results Tiopronin injection has no obvious stimulatory effect on the marginal ear veins of rabbits,no obvious influence of hemolyzation and agglutination on rabbit red blood cell,and no allergic action on guinea pigs.Conclusion The safety of soled tiopronin injection used as the clinical intravenous injection is good.

关 键 词：硫普罗宁 血管刺激 溶血 过敏 

分 类 号：Q95-33[生物学—动物学]