顶空气相色谱法测定盐酸倍他司汀有机溶剂残留量  

Determination of the Organic Solvent Residue in Betahistine Hydrochloride by Headspace GC

作　　者：石杰[1] 吴家锴[1] 闻京伟[2] 陶鹏丽[1] 王丽杰[1] 

机构地区：[1]郑州大学化学系,河南郑州450001 [2]河南省食品药品检验所,河南郑州450003

出　　处：《郑州大学学报（理学版）》2010年第3期90-92,107,共4页Journal of Zhengzhou University:Natural Science Edition

基　　金：河南省科技攻关项目;编号0496430006;河南省自然科学基础研究项目;编号0411021200

摘　　要：采用顶空气相色谱法研究盐酸倍他司汀原料药中残留溶剂异丙醇、三氯甲烷含量的测定方法.异丙醇在20～400 mg·L^-1范围内回归方程为：A=115 127.9C-116 867,r=0.998 5;三氯甲烷在1.1～88 mg·L^-1范围内回归方程为：A=259 942C-290 048,r=0.997 9,线性关系良好,方法简便易行,结果准确.A headspace GC method is used to determine the residual organic solvent of the isopropyle alcohol and trichoromthane in betahistine hydrochloride.Linear correlation is obtained over the range of 20～400 mg·L^-1 for isopropyle alcohol,with the regression equation is A=115 127.9C116 867,r=0.998 5;and over the range of 1.1～88 mg·L^-1,the regression equation is A=259 942 C-290 048,r=0.997 9 for trichoromethane.The method is easily operative and the result is accurate for determination of solvent residue in betahistine hydrochloride.

关 键 词：顶空气相色谱法 有机溶剂残留 盐酸倍他司汀 

分 类 号：R917[医药卫生—药物分析学]