注射用二丁酰环磷腺苷钙的血管刺激性、溶血性和过敏性研究  

Study on Vascular Stimulation,Hemolytic,and Anaphylactic of Calcium Dibutyryladenosine Cyclophosphate for Injection

作　　者：宋晓娜[1] 王子彪[1] 周丽[2] 

机构地区：[1]沈阳市中医药学校,110300 [2]石家庄四药有限公司,050000

出　　处：《中国医药指南》2010年第27期5-7,共3页Guide of China Medicine

摘　　要：目的观察注射用二丁酰环磷腺苷钙是否具有血管刺激性、溶血性和致过敏性性反应。方法以豚鼠及家兔为实验动物,给予注射用二丁酰环磷腺苷钙后观察有无红肿、充血、出血和坏死等刺激作用及溶血和过敏现象。结果滴注部位未出现明显的红肿、充血、坏死等血管刺激反应及过敏现象;对家兔红细胞未产生溶血和凝集作用。结论注射用二丁酰环磷腺苷钙无血管刺激性、溶血性及过敏性反应,该制剂的安全性得到确证。Objective To observe whether Calcium Dibutyryladenosine Cyclophosphate for injection has vascular stimulation,hemolytic,and anaphylactic. Method Using guinea pigs and rabbits as experimental animals,which were injected Calcium Dibutyryladenosine Cyclophosphate for injection,we have been observed the stimulation reaction on blood vessel of rabbits,hemolytic and agglomeration reaction on vitro-body red cell of rabbits and the anaphylactic reaction on guinea pigs. Results The results showed no stimulation reaction on blood vessel of rabbits,no hemolytic and agglomeration reaction on vitrobody red cell of rabbits and no anaphylactic action on guinea pigs. Conclusion Calcium Dibutyryladenosine Cyclophosphate for injection has no stimulation,hemolytic,and anaphylactic reaction. This safety of preparation was proved.

关 键 词：注射用二丁酰环磷腺苷钙 血管刺激性 溶血性 过敏性 

分 类 号：R969.2[医药卫生—药理学]