大鼠饮盐行为的个体发生的研究  

STUDIES OF ONTOGENY OF SALT INTAKE BEHAVIOR IN THE RAT PUPS

作　　者：杨振芳[1] 么淑珍[1] 

机构地区：[1]天津医科大学基础医学院

出　　处：《天津医科大学学报》1999年第2期17-18,共2页Journal of Tianjin Medical University

摘　　要：研究不同性别的发育期大鼠饮盐行为的发生年龄及其与大鼠血浆醛固酮（ＡＬＤＯ）水平之间的关系，为研究高血压病提供基础资料。方法：用自控泵经口腔导管给大鼠灌注３％盐水，记录大鼠的饮盐水量。结果：禁盐能引起１３ｄ龄及１３ｄ龄以上大鼠的饮盐行为。而不能引出１３ｄ龄以下幼鼠的饮盐行为。幼鼠的饮盐行为无显著的性别差异。这与禁盐引起各年龄组大鼠的血浆ＡＬＤＯ水平都显著升高的现象不一致。结论：大鼠饮盐行为的发生与大鼠的年龄有关，与大鼠脑的发育，特别是与大鼠的饮盐中枢的发育及完善有关。Objective: Developing male and female rats were examined for the age of onset of the salt intake behavior,and for the relationship between the sodium appetite and the concentration of the plasma ALDO of the rat. Methods: Rats were depleted by a combination of pharmacological natriuresis (using lasix)and maternal deprivation, Then rats were infused with 3% salt solution through oral catheters by using controled outmatically pumps Results: The appetite was reliably evident from 13 days of age in both male and female rats, but no reliably evident from the age of 12 days and under The depleted rats drink more 3% salt solution than that control rats do There was no difference between male and female rats Conclusion: The data suggests that all necessary components of the mechanism for the expression of sodium appetite are assembled at about 13days of age in the rat brain

关 键 词：饮盐行为 高血压 病理学 个体发生 

分 类 号：R544.102[医药卫生—心血管疾病] R155.1[医药卫生—内科学]