依帕司他联合灯盏花素治疗2型糖尿病周围神经病变的疗效观察  

Efficacy Observation of Epalrestat Combined with Breviscapine in the Treatment of Type 2 Diabetic Peripheral Neuropathy

作　　者：王曦[1] 王剑虹[1] 

机构地区：[1]贵州省遵义医院,遵义市563002

出　　处：《中国药房》2010年第36期3415-3416,共2页China Pharmacy

摘　　要：目的:观察依帕司他联合灯盏花素注射液治疗2型糖尿病周围神经病变的临床疗效。方法:选择2型糖尿病周围神经病变患者48例,均给予灯盏花素注射液40 mg静脉滴注,qd;依帕司他50 mg,口服t,id。连用4周。观察患者治疗前、后神经系统症状及体征变化,并测定治疗前、后患者四肢的神经传导速度,膝、跟腱反射以及肝肾功能等。结果:依帕司他联合灯盏花素注射液治疗后,患者神经系统症状及体征变化均明显好转,各神经传导速度与治疗前比较均有显著性差异(P<0.05)。治疗过程中2例患者出现眩晕、心悸,1例患者出现恶心、上腹部饱胀,均未停药,1～3 d后缓解,其余患者未见其他明显不良反应。治疗后肝肾功能无明显变化。结论:依帕司他联合灯盏花素注射液治疗2型糖尿病周围神经病变安全、有效。OBJECTIVE：To observe the clinical efficacy of epalrestat combined with Breviscapine injection in the treatment of type 2 diabetic peripheral neuropathy.METHODS：48 patients with type 2 diabetes complicating with peripheral neuropathy were all given Breviscapine injection 40 mg once a day by intravenous drip and oral dose of epalrestat 50 mg three times a day for 4 weeks.The changes of symptoms and signs of nerve system were observed before and after treatment,and nerve conductive velocity,knee jerk and achilles tendon reflex,liverkidney function were detected too.RESULTS：After treatment,the symptoms and signs of nerve system were obviously improved.There was significant difference in nerve conductive velocity before and after treatment（P0.05.） During the period of treatment,2 patients suffered from dizziness and palpitation and 1 patient nausea and fullness of upper abdomen.They neither stop taking medicine and the symptoms were relieved after 1～3 days.ADR wasnt’ found in other patients.After treatment liverkidney function wasnt’ improved obviously.CONCLUSION：Epalrestat and Breviscapine injection are safe and effective in the treatment of type 2 diabetic peripheral neuropathy.

关 键 词：糖尿病 周围神经病变 灯盏花素 依帕司他 

分 类 号：R587.2[医药卫生—内分泌]