妊娠妇女甲状腺功能减退症及危险因素分析  

Hypothyroidism and its risk factors among pregnant women

作　　者：李建宁[1] 周黎黎[1] 赵迎春[1] 何岚[2] 高显兰 张永红 王新荣 

机构地区：[1]新疆克拉玛依市中心医院内分泌科,834000 [2]西安交通大学第一附属医院内分泌科 [3]新疆克拉玛依市人民医院妇产科 [4]新疆独山子石化医院妇产科

出　　处：《中国公共卫生》2010年第9期1174-1176,共3页Chinese Journal of Public Health

基　　金：2007年克拉玛依市指导性科技计划项目(sk2007-20)

摘　　要：目的探讨妊娠妇女甲状腺功能减退症的流行病学特征及危险因素。方法选取妊娠妇女2 076人及育龄妇女266人进行问卷调查和甲状腺功能、甲状腺过氧化物酶抗体(TPOAb)和尿碘测定。结果妊娠妇女及育龄妇女甲状腺功能减退症患病率分别为5.3%及6.8%;妊娠妇女甲状腺功能减退症在高尿碘组占7.6%,高于足量尿碘组及超足量尿碘组(P=0.026),甲状腺过氧化物酶抗体(TPOAb)阳性率为23.9%,高于甲状腺功能正常者(P=0.000);多因素Logistic分析表明,高尿碘、TPOAb阳性为甲状腺功能减退症的独立危险因素,OR值分别为2.21(95%CI=1.36～3.60)及4.68(95%CI=2.74～7.98)。结论自身免疫性甲状腺疾病和过量碘摄入是妊娠妇女甲状腺功能减退症的重要因素且密切相关。Objective To determine the epidemiological characteristics and risk factors of hypothyroidism among pregnant women.Methods Thyroid function and urinary iodine of 2076 pregnant women and 266 women at gestational age were measured and ultrasound inspection of thyroid was conducted among the women.Results The prevalence of hypothyroidism of pregnant women and women at gestational age were 5.3% and 6.8%,respectively.The prevalence of hypothyroidism was 7.6% among the pregnant women with high urinary iodine,which was significantly higher than that of the adequate urinary iodine group and very high urinary iodine group（P=0.026）.Positive thyroid peroxidase antibody ratio of pregnant women in hypothyroidism group was 23.9%,which was significantly higher than those of the normal group（P=0.000）.Multinomial logistic analysis showed that high urinary iodine and positive thyroid peroxidase antibody were independent risk factor of hypothyroidism with the odds ratio values of 2.21（95% confidence interval1.36-3.60） and 4.68（95%CI 2.74-7.98）,respectively.Conclusion The autoimmune thyroiditis and iodine overdose are important factors and closely associated with hypothyroidism among pregnant women.

关 键 词：甲状腺功能减退症 妊娠 甲状腺过氧化物酶抗体 尿碘 

分 类 号：R581.2[医药卫生—内分泌]