白川胶囊对左心肥厚及其相关指标的作用研究  

Effects of Bai-Chuan Capsule on Left Ventricular Hypertrophy and Correlative Indexes

作　　者：张燕[1] 贺浪冲[1] 段海洁[1] 展颖转[1] 

机构地区：[1]西安交通大学医学院,陕西西安710061

出　　处：《中药材》2010年第8期1290-1292,共3页Journal of Chinese Medicinal Materials

基　　金：国家自然科学基金(30730110);陕西省"13115"创新工程计划

摘　　要：目的:探讨白川胶囊对自发性高血压大鼠(SHR)血压、左心肥厚(LVH)及血浆中血管紧张素Ⅱ(AngⅡ)和醛固酮(ALD)含量的变化的影响。方法:选取自发性高血压大鼠和京都种Wistar大鼠(WKY)分别作为模型对照和正常对照,用白川胶囊进行为期3个月的干预,期间监测血压变化,卡托普利作为阳性对照药。大鼠处死后称量左心室质量并计算左心肥厚指数,对左心室进行病理生态学观察,用放射免疫法测定血浆中AngⅡ和ALD。结果:白川胶囊在平稳降压的同时可以抑制左心肥厚,并且显著下调大鼠血浆中AngⅡ和ALD的水平。结论:白川胶囊对SHR大鼠的左心肥厚及血浆中AngⅡ和ALD水平有一定的抑制作用。Objective： To investigate the effects of Bai-Chuan capsule（BC） on the Left Ventricular Hypertrophy in spontaneously hypertensive rats（SHR）.Methods：Taking SHR and Wistar Kyoto rats（WKY） as the model group and the control group respectively,Captopril as positive drug,administered BC 0.3 g/kg,Captopril 3.75 mg/kg or 0.5% CMC-Na to each group by ig for 3 months,and measured the change of blood pressure.The left ventricular mass index was calculated after rats were sacrificed.Left ventricle was used to pathological observations,plasma angiotensinⅡ and aldosterone were measured by radioimmunoassay.Conclusion：BC can inhibit left ventricular hypertrophy,plasma level of angiotensinⅡ and aldosterone to some extent in SHR.

关 键 词：白川胶囊 高血压 左心肥厚 原发性高血压大鼠 

分 类 号：R285.5[医药卫生—中药学]