复方腮腺炎巴布剂的体外透皮释放研究  

Study on In vitro Release and Transdermal Behaviors of Mumps Cataplasm of Complex Prescription

作　　者：宋金燕[1] 郭增军[1] 郑娜[1] 吴楠[1] 毛俊俊[1] 庞晓明[1] 

机构地区：[1]西安交通大学医学院,陕西西安710061

出　　处：《中药材》2010年第8期1330-1332,共3页Journal of Chinese Medicinal Materials

基　　金：国家级大学生创新实验(0116-08120027)

摘　　要：目的:考察复方腮腺炎巴布剂的药物体外释放和透皮行为。方法:采用垂直式Franz扩散池。HPLC测定接收液中双氯芬酸钠(DCS)含量,紫外分光光度法测定黄酮类化合物含量。结果:DCS和黄酮类化合物的累积透皮率分别为32%、21%,DCS和黄酮类化合物的体外释放率分别为47%、42%。结论:复方腮腺炎巴布剂的药物透皮行为属于零级动力学过程,体外释放符合Higuchi方程。Objective：To investigate the in vitro release and transdermal behaviors of mumps cataplasm of complex prescription.Methods：The improved Franz difficusion was used and the concentration of drugs was detected.DCS was determined by HPLC and flavanoid contents were determined by UV.Results：The acumulation skin permeation percentage of DCS and flavanoid was 32% and 21%,respectively,the in vitro release percentage of DCS and flavanoid was 47% and 42%,respectively.Conclusion：The transdermal behavior of mumps cataplasm of complex prescription is an zero-order kinetics progress.The in vitro release behavior is in accordance with the Higuchi equation.

关 键 词：巴布剂 双氯芬酸钠 黄酮类化合物 透皮 释放 

分 类 号：R944.9[医药卫生—药剂学]