HbA1c与血浆Cys-C、β_2-MG在Ⅱ型糖尿病肾病早期的诊断  

Early Diagnostic Value of Plasma HbA1c、 Cys-C、β_2-MG in Patients with Diabetic Nephropathy Ⅱ

作　　者：程多智[1] 毛达勇[1] 朱名安[1] 康敏[1] 谭莹[1] 

机构地区：[1]郧阳医学院附属太和医院检验部,湖北十堰市442000

出　　处：《医药论坛杂志》2010年第16期4-5,8,共3页Journal of Medical Forum

摘　　要：目的探讨糖化血红蛋白(HbA1c)与血浆Cys-C、β2-MG在Ⅱ型糖尿病肾病早期的诊断价值。方法根据尿清蛋白排泄率(UAER)将60例Ⅱ型糖尿病分为三组,即正常组、微量组、大量组,和40例健康对照组的同时进行血浆Cys-C、β2-MG、BUN、Crea与HbA1c同时测定,并作比对分析。结果微量组和大量组血浆Cys-C、β2-MG与HbA1c与健康正常对照组比较均有非常显著增高,正常组与健康对照组比较差异无统计学意义。大量组阳性率分别为100%、100%、87.5%;微量组阳性率分别为Cys-C(93.1%)>β2-MG(79.3%)>HbA1c(55.2%)>Crea(34.5%)>BUN(20.7%)。结论 HbA1c与血浆Cys-C、β2-MG在Ⅱ型糖尿病肾病早期的诊断中有较高的阳性检出率,可作为糖尿病肾病的早期诊断指标。Objective To evaluate the HbA1c、β2-MG、Cys-C as three marker of early diagnosis in patients with diabetic nephropathy Ⅱ（DN）.Methods Sixty patients with Ⅱ DN were divided into three groups according to urinary albumin excretion rate（UAER）,that is normal,micro and mass group.Plasma Cys-C、β2-MG、BUN、Crea、HbA1c were detected and parallelly contrasted in the three groups and control group with twenty healthy people.Results Compared with the control group,the plasma Cys-C、β2-MG、HbA1c of micro and mass group both significantly increased and the normal group had no significant difference.The positive rate of Cys-C、β2-MG、HbA1c in mass group was respectively 100%、100%、87.5%;the positive rate in micro group as follows： Cys-C（93.1%） β2-MG（79.3%） HbA1c（55.2%） Crea（34.5%） BUN（20.7%）.Conclusion The plasma HbA1c、 Cys-C、β2-MG have high positive rates in patients with diabetic nephropathy Ⅱ（DN）,they can be used as early diagnostic marker of diabetic nephropathy Ⅱ especially Cys-C.

关 键 词：Β2微球蛋白 微量清蛋白 早期诊断 糖化血红蛋白 

分 类 号：R446.112[医药卫生—诊断学]