输血感染HIV患者外周血T淋巴细胞亚群变化研究  

Study of Variation of Peripheral T Lymphocyte Subsets of Patients Infected HIV by Blood Transfusion

作　　者：孙长宇[1] 汤展展[1] 

机构地区：[1]郑州大学第一附属医院感染科,郑州市450052

出　　处：《医药论坛杂志》2010年第16期28-29,共2页Journal of Medical Forum

基　　金：河南省医学科学院艾滋病科技攻关项目[200413]

摘　　要：目的研究输血感染的艾滋病患者和HIV携带者外周血T淋巴细胞亚群的表达。方法利用白细胞分类和流式细胞分析法对20例HIV携带者和20例AIDS患者外周血淋巴细胞中CD3+,CD4+,CD8+的表达及绝对数进行检测。结果 AIDS患者组CD3+淋巴细胞数较正常值显著下降(P<0.05);HIV感染组与艾滋病组的CD4+T淋巴细胞数显著下降(P<0.01);CD8+淋巴细胞数显著增高(P<0.01);CD4/CD8+比值倒置。结论感染HIV后外周血CD4+T淋巴细胞数显著下降,随病情进展下降更显著。Objective To explore the variation of peripheral T lymphocyte subsets of patients infected human immunodeficiency virus（HIV） by blood transfusion.Methods Using the lymphocyte classification and streaming cell analysis on expression and absolute number testing of peripheral blood lymphocyte CD3＋,CD4＋,CD8＋ of 20 cases of HIV carrier and 20 cases of acquired immune deficiency syndrome（AIDS）.Results CD3＋ lymphocyte number of AIDS group decreased more significantly than normal group（P0.05）,CD4＋T lymphocyte number of HIV and AIDS group decreased significantly（P0.01）,CD8＋ lymphocyte number increased significantly（P0.01）,CD4＋/CD8＋ ratio inversion significantly.Conclusion The number of peripheral CD4＋T lymphocyte decreased significantly after HIV infecting,the more significantly decline with progression.

关 键 词：人类免疫缺陷病毒 获得性免疫缺陷综合征 淋巴细胞亚群 流式细胞分析法 

分 类 号：R512.91[医药卫生—内科学]