基于类Hopfield脉冲神经网络模型由突触缺失导致海马CA3区联想记忆功能障碍的建模仿真研究  

Modeling and simulating study on disorder of associative memory function of hippocampal CA3 region caused by synaptic deletion based on Hopfield-like spiking neural network model

作　　者：赵旺兄[1] 乔清理[1] 王丹[1] 

机构地区：[1]天津医科大学生物医学工程系,300070

出　　处：《国际生物医学工程杂志》2010年第4期201-204,211,共5页International Journal of Biomedical Engineering

基　　金：天津市自然科学基金（08JCYJC03300）

摘　　要：目的 建立1个类Hopfield脉冲神经网络模型,仿真海马中突触缺失导致的其联想记忆功能障碍.方法 根据海马CA3区的解剖结构,建立1个具有自联想记忆功能和异联想记忆功能的3层类Hopfield脉冲神经网络模型,并用Matlab对网络的2种联想记忆功能进行仿真,并根据Ruppin的‘突触缺失＇理论,仿真了由突触缺失导致的CA3区联想记忆功能障碍.结果 随着突触缺失水平的增加,网络的2种联想记忆能力均下降.结论 海马CA3区神经元突触缺失不仅导致其自联想记忆能力下降,也会导致其异联想记忆能力下降.Objective A spiking Hopfield-like neural network was proposed and used to simulate the disorder of hippocampal associative memory disorder caused by synaptic deletion.Methods A three-layered Hopfield-like spiking neural network model with auto-associative memory function and hetero-associative memory function was proposed according to anatomical structure of hippocampal CA3,and both associative memories of the models were simulated under Matlab platform.Disorder of hippocampal associative memory was also simulated according to Ruppin＇s ＇synaptic deletion＇ theory.Results With the increasing of synaptic deletion level,both associative memory functions impaired gradually.Conclusion Synaptic deletion of hippocampal CA3 region can lead to the disorder of autoassociative memory as well as heteroassociative memory.

关 键 词：海马CA3 突触缺失 类Hopfield网络模型 自联想记忆 异联想记忆 

分 类 号：TP183[自动化与计算机技术—控制理论与控制工程] R338[自动化与计算机技术—控制科学与工程]