内质网应激对胰岛β细胞凋亡的损伤效应  

Injury apoptosis effects of Endoplasmic reticulum stress on the pancreatic β-cell

作　　者：陈闻佳[1] 刘乙斌 

机构地区：[1]福建医科大学附属协和医院内分泌科,福州350000 [2]福建省内分泌研究所

出　　处：《国际生物医学工程杂志》2010年第4期228-230,234,共4页International Journal of Biomedical Engineering

摘　　要：胰岛β细胞具有高度发达的内质网,是对内质网应激最敏感的细胞之一.内质网应激是胰岛β细胞在受到应激条件下,细胞的适应性反应.内外环境中的多种因素：氧化损伤、脂毒性、细胞因子作用等均可打破内质网的稳态,导致蛋白质折叠障碍或错误折叠,进而触发内质网应激.严重而持久的应激将导致β细胞的凋亡,参与多种代谢性疾病乃至多种疾病的发生.综述多种因素诱导的内质网应激对胰岛β细胞的损伤效应.As one of the most sensitive cells of endoplasmic reticulum stress,pancreatic βcells have an abundance of endoplasmic reticulum .It is the adaptive response of pancreatic β cells under Endoplasmic reticulum stress conditions.Internal and external factors in the environment such as oxidative damage,lipid toxicity and the effect of cytokines in the endoplasmic reticulum could breake the steady-state,resulting in barriers to folding or misfolding of protein,thereby to trigger endoplasmic reticulum stress.Serious and lasting stress will lead to β cell apoptosis,involved in a variety of metabohc diseases as well as a variety of diseases.This article gives a review on the injury effects of multi-factor induced endoplasmic reticulum stress on the pancreatic β-cell

关 键 词：内质网应激 胰岛Β细胞 凋亡 

分 类 号：R587[医药卫生—内分泌]