降压益肾颗粒对自发性高血压大鼠(SHR)ET-1和TGF-β_1表达的实验研究  

Empirical Study of Jiangya Yishen Particles on ET-1 and TGF-β1 Expression in Spontaneously Hypertensive Rats (SHR)

作　　者：朱萱萱[1] 严冬[1] 严士海[1] 吴旭彤[1] 符蕾[1] 秦晓康[1] 

机构地区：[1]南京中医药大学附属医院,江苏南京210029

出　　处：《中华中医药学刊》2010年第9期1805-1806,共2页Chinese Archives of Traditional Chinese Medicine

基　　金：江苏省高校自然科学研究项目

摘　　要：目的:初步探讨降压益肾颗粒对自发性高血压大鼠(SHR)的降压效果及对血浆ET-1和TGF-β1含量的影响。方法:选择8周龄雄性SHR50只,随机分为SHR模型组、降压益肾颗粒低、中、高剂量组、盐酸贝那普利组,同时以同源性Wistar大鼠10只作为正常对照组,药物干预12周。每周用无创尾动脉套袖法测量各组大鼠血压;第8周和12周后取血,测定血清中ET-1和TGF-β1含量。结果:SHR模型组第8周和12周血浆中ET-1和TGF-β1含量明显升高,与Wistar组比较具有显著性差异(P<0.01),降压益肾颗粒可明显降低SHR血压和血清中ET-1和TGF-β1含量,与SHR模型组比较具有显著性差异(P<0.01),结论:降压益肾颗粒对SHR有较好降压作用,其降压机制可能与降低SHR血浆ET-1和TGF-β1含量有关。Objective：Studied the Jiangya Yishen particles to effect on low blood pressure and its plasma ET-1 and TGF-β1 levels in spontaneously hypertensive rats （SHR）. Methods： 8-week-old 50 male SHR rats were randomly divided into SHR model group, Jiangya Yishen particles low, middle and high-dose group, benazepril hydrochloride group, meanwhile use d homologous Wistar rats 10 as normal control group, drug intervention for 12 weeks. Used the non-invasive arterial caudilis sleeve measurement rats in each group; after the first 8 weeks and 12 weeks got blood ,measured ET-1 and TGF-β1 levels in serum. Results： The first 8 weeks and 12 weeks SHR model group ET-1 and TGF-β1 were significantly increased in plasma ,compared with the Wistar group was significant difference （P0.01）, Jiangya Yishen particles can significantly low SHR blood pressure Y and ET-1 and TGF-β1 levels in serum, compared with the SHR model group were significant difference （P0.01）. Conclusion： The Jiangya Yishen particles had better antihypertensive effect on SHR, which may be associated with reducing ET-1 and TGF-β level in SHR plasma.

关 键 词：降压益肾颗粒 SHR ET-1 TGF-Β1 

分 类 号：R285.5[医药卫生—中药学]