祛异康对子宫内膜异位症模型大鼠血浆TXB_2和6-Keto-PGF_(1α)的影响  

Effect of QuYiKang on TXB_2 and 6-Keto-PGF_(1α) of Endometriosis in Rats

作　　者：杨鉴冰[1] 杨帆[2] 

机构地区：[1]陕西中医学院,陕西咸阳712046 [2]西安医学院第二附属医院,陕西西安710000

出　　处：《中华中医药学刊》2010年第9期1881-1883,共3页Chinese Archives of Traditional Chinese Medicine

基　　金：陕西省教育厅自然科学专项课题(07JK236)

摘　　要：目的:观察祛异康对子宫内膜异位症模型大鼠血浆血栓烷B2(TXB2)和6-酮-前列腺素F1α(6-Keto-PGF1α)水平的影响,探讨其治疗子宫内膜异位症的作用机理。方法:采用手术移植法建立大鼠子宫内膜异位症模型,随机分为对照组、模型组、祛异康组、丹那唑组。造模成功各组给药4周,放射免疫法检测血浆中TXB2和6-Keto-PGF1α的含量。结果:与模型组比较祛异康组、丹那唑组具有明显降低异位症大鼠血浆中TXB2的含量(P<0.05);显著升高血浆中6-Keto-PGF1α的含量(P<0.05)。结论:祛异康能明显抑制异位症模型大鼠异位内膜的生长,其治疗机理可能是通过降低异位症大鼠血浆中TXB2的含量及升高6-Keto-PGF1α的含量从而改善子宫异常收缩和子宫血管舒缩功能紊乱,减轻子宫缺血、缺氧、痉挛、疼痛症状而达到治疗内异症的目的。Objective：To observe the effect of QuYiKang on TXB2 and 6-Keto-PGF1αof endometriosis in rats and to study the possible therapeutic mechanism. Methods： Models of endometriosis in rats were established by operation transportation, which were divided into control group, the modle group, QuYiKang group and Danazol group randomly. Medicines were continually given to the rats in four weeks, and the contents of TXB2 and 6-Keto-PGF1α in plasma were detected by radioimmunoassay. Results： Compared with model group, the contents of TXB2 were more significantly decreased and 6-Keto-PGF1α were obviously increased in QuYiKang group and Danazol group （P0.05）.Conclusion： QuYikKang can control the development of ectopic endometrium; QuYikKang also can improve abnormal uterine contractions and alleviate symptoms of uterine ischemia, hypoxia, spasm, pain through decreasing the contents of TXB2 and increasing of 6-Keto-PGF1α.

关 键 词：子宫内膜异位症 TXB2 6-KETO-PGF1Α 中药祛异康 实验研究 

分 类 号：R285.5[医药卫生—中药学]