甘草酸二铵磷脂复合物水针剂的处方研究  

Study on Formulation of Diammonium Glycyrrhizinate Phospholipid Complex Injection

作　　者：茹仁萍[1] 陈晓瑾[1] 孙宇[1] 

机构地区：[1]杭州市第六人民医院,浙江杭州310014

出　　处：《中华中医药学刊》2010年第9期1932-1934,共3页Chinese Archives of Traditional Chinese Medicine

基　　金：杭州市科技局资助项目(20051333838)

摘　　要：目的:确定合适的甘草酸二铵磷脂复合物注射剂处方。方法:分别考察了溶媒、溶液pH值对注射剂稳定性的影响,并通过筛选不同种类和浓度的稳定剂确定最适处方。结果:采用pH8.5的注射用水为溶媒,0.2%去氧胆酸钠为稳定剂,所制备的甘草酸二铵磷脂复合物注射液的平均粒径为50.9nm,Zeta电位为-54.2mV,过氧化值合格。注射剂在40℃高温和强度4500LUX光照下放置10天理化性质没有发生明显变化。结论:按优化处方得到的注射剂粒径和电位符合肝脏靶向要求,且质量稳定。Objective：To optimize the formulation of diammonium glycyrrhizinate phospholipid complex injection.Methods： Factors to influence stability, including solvent, pH value, as well as the stabilizers, were investigated.Results：The optimal formulation was made of water solution with pH8.5, 0.2% sodium deoxycholate as the stabilizer. The average particle size was 50.9nm, the Zeta potential was -54.2mV and the POV was under limit. The injection was stable under 40℃ temperature or 4500Lux illumination for ten days.Conclusion： The appropriate formulation can be used to prepare diammonium glycyrrhizinate phospholipid complex injection successfully.

关 键 词：甘草酸二铵磷脂复合物 水针剂 处方优化 

分 类 号：R284.1[医药卫生—中药学]