西沙必利对大鼠胃肠消化间期移行性复合运动的作用  

Effect of Cisapride on Gastrointestinal interdigestive MigratingMotor Complex in Rats

作　　者：王玲[1] 周吕[1] 侯晓菲[1] 

机构地区：[1]中国医学科学院中国协和医科大学基础医学研究所生理研究室

出　　处：《基础医学与临床》1999年第2期47-52,共6页Basic and Clinical Medicine

基　　金：西安杨森科学研究委员会资助

摘　　要：本研究在胃、十二指肠慢性埋植应力传感器的大鼠上，观察了大鼠胃肠移行性复合运动（ＭＭＣ）的特点及西沙必利对ＭＭＣ的作用及与胃动素释放的关系。结果表明：（１）空腹时。大鼠胃、十二指肠可以记录到典型的ＭＭＣ活动。（２）西沙必利可增强ＭＭＣ收缩活动，分别使胃、十二指肠ＭＭＣⅢ相延长９３％和３５％。（３）西沙必利使胃肠ＭＭＣⅢ相时的血浆胃动素浓度升高。（４）给予抗胃动素血清、５－ＨＴ４受体拮抗剂及阿托品可抑制西沙必利对ＭＭＣ的收缩作用。上述结果提示：西沙必利增强胃肠收缩活动的作用机制．除通过肠神经系统５－ＨＴ，受体引起ＡＣｈ释放外，还通过激发胃动素的释放，使ＭＭＣⅢ相收缩增加。The characteristics of interdigestive migrating motor complex (MMC) and the effect of cisaprjde(Prepulsid) on gastrointestinal MMC and plasma motilin concentration were studied in conscious ratsimplanted with strain gauge.The results showed:(l) MMC pattern could be clearly recorded onstomach and duodenum in fasting state in rats, (2) cisapride induced a significant increase in gas-trointestinal MMC contractile activity,and the duration of the gastric and duodenal phase III increasedby 93% and 35% respectively. (3) cisapride caused a significant increase of plasma motilinconcentration,(4) the effects of cisapride were blocked by anti-motilin serum, 5-HT4 antagonist andatropine.The results suggest that cisapride may exert stimulatory effects on gastrointestinal motilityby stimulating 5-HT4 receptor in the enteric nervous system (ENS), while it may also induce MMCphase Ill motor activity via facilitating motilin release.

关 键 词：西沙必利 移行性复合运动 胃动素 胃肠运动 MMC 

分 类 号：R975[医药卫生—药品]