草苁蓉提取物对高脂血症家兔血浆脂蛋白脂质过氧化的影响  

Effect of Boschniakia rossica Extracts on Lipid Peroxidation of Lipoproteins in Rabbits with Hyperlipidemia

作　　者：尹学哲[1] 许惠仙[1] 金爱花[2] 全吉淑[2] 

机构地区：[1]延边大学医院,吉林延吉133000 [2]延边大学基础医学院,吉林延吉133000

出　　处：《中国实验方剂学杂志》2010年第11期132-134,共3页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：国家自然科学基金项目(30360113);吉林省科技发展计划资助项目(200705426)

摘　　要：目的:研究草苁蓉提取物(BRE)对实验性高脂血症兔血浆脂蛋白抗脂质过氧化作用的影响。方法:高脂饲料喂养法建立兔高脂血症模型,连续给药8周后分离血浆脂蛋白,观察各血浆脂蛋白过氧化脂质(LPO)含量及低密度脂蛋白(LDL)氧化易感性的变化。结果:饲喂BRE后高脂血症兔血浆总胆固醇(TC)、极低密度脂蛋白胆固醇(VLDL-CH)和低密度脂蛋白胆固醇(LDL-CH)水平明显降低;血浆总LPO和脂蛋白LPO含量明显减少;在体外进行氧化修饰时,LDL氧化延滞时间明显延长。结论:BRE可降低高脂血症兔血脂水平和血浆脂蛋白脂质过氧化程度,增强LDL抗氧化修饰能力,因此能够起到防治动脉粥样硬化症的积极作用。Objective：To study the inhibitory effect of Boschniakia rossica extracts（BRE） on lipid peroxi-dation of plasma lipoproteins in rabbits with hyperlipidemia.Method：The hyperlipidemic model were established by feeding rabbits with high-fat diet.After 8 weeks of treatment,plasma lipoproteins were isolated,and then lipid peroxide（LPO） and susceptibility of low density lipoprotein（LDL） to oxidation was investigated.Result：After the administration with BRE,the levels of plasma total cholesterol（TC）,very low density lipoprotein cholesterol（VLDL-CH） and low density lipoprotein cholesterol（LDL-CH） in hyperlipidemic rabbits were significantly re-duced;LPO levels of plasma and lipoproteins were significantly decreased;and the lag phage of LDL oxidation curve in vitro was noticeably prolonged.Conclusion：BRE,which can reduce blood lipids,decrease the lipid per-oxidizability of lipoproteins and promote resistance to LDL oxidation,may be useful in the prevention and treatment of atherosclerosis.

关 键 词：草苁蓉 高脂血症 血脂 脂蛋白 过氧化脂质 氧化易感性 

分 类 号：R285.5[医药卫生—中药学]