胃和冲剂Ⅱ号对慢性萎缩性胃炎大鼠病理形态学及抗氧化酶活性的影响  

Effect of Weihe Ⅱ Powder on Pathomorphological Changes and Anti-oxidative Activities in Rats with Chronic Atrophic Gastritis

作　　者：王艳[1] 麻春杰[1] 宋美丹[1] 王滨[1] 康永[1] 董平[1] 

机构地区：[1]内蒙古医学院中医学院,呼和浩特010110

出　　处：《中国实验方剂学杂志》2010年第12期129-131,共3页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：内蒙古医学院博士启动基金项目(200802)

摘　　要：目的:研究胃和冲剂Ⅱ号对大鼠慢性萎缩性胃炎(CAG)的治疗作用,并探讨其作用机制。方法:采用综合法建立CAG大鼠模型,造模成功后给予胃和冲剂Ⅱ号治疗,观察此方对CAG大鼠胃黏膜组织形态及血清抗氧化酶活性的影响。结果:胃和冲剂Ⅱ号明显改善CAG大鼠病损程度,增加CAG大鼠胃窦黏膜腺体层厚度(P<0.01)、降低胃窦黏膜肌层厚度(P<0.05),使腺体萎缩得到恢复,炎症反应减轻;可提高CAG大鼠血清超氧化物歧化酶(SOD)、谷胱甘肽过氧化物酶(GSH-Px)活性、降低MDA含量(P<0.05)。结论:胃和冲剂Ⅱ号能改善和逆转试验性CAG大鼠胃黏膜的病理变化,对CAG具有良好的治疗作用。其机制可能与增强抗氧化酶活性、减轻自由基损伤有关。Objective： To study the effect and the mechanism of Weihe Ⅱ Powder on rats with chronic atrophic gastritis（CAG）.Method： Chronic atrophic gastritis of rat was established through a synthesized method.The rats were treated with Weihe Ⅱ Powder after the model was made successfully.The influences of the powder on morphology of gastric mucosa and anti-oxidative enzyme activities in serum of the rats with CAG were investigated.Result： Weihe Ⅱ Powder could reduce the injuries in CAG rats,increase the thickness of mucosa glandular（P 0.01） to restore the gastric mucosa,reduce inflammatory reactions,enhance activities of SOD and GSH-Px,decrease content of MDA（P 0.05）.Conclusion： Weihe Ⅱ Powder could improve pathomorphological changes in CAG rats.It might be related with enhancement of anti-oxidative enzyme activities to avoid injuries induced by free radicals.

关 键 词：胃和冲剂 慢性萎缩性胃炎 病理形态学 超氧化物酶歧化酶 谷胱甘肽过氧化物酶 丙二醛 

分 类 号：R285.5[医药卫生—中药学]