得康口服液抗5-Fu致小鼠食量、体重下降及白细胞减少的实验研究  

The Experimental Study on the Effects of Dekang Oral Liquid on the Toxicity of 5 Fu

作　　者：杨广文[1] 张素英[1] 张晓健[1] 马俊英 王毓銮[1] 

机构地区：[1]山西省肿瘤医院

出　　处：《山西中医》1999年第2期41-42,共2页Shanxi Journal of Traditional Chinese Medicine

摘　　要：目的：观察得康口服液拮抗５－Ｆｕ引起小鼠食量、体重下降及ＷＢＣ减少的作用。方法：将６０只雄性昆明种小白鼠随机分为３组，观察组用得康口服液与５－Ｆｕ联合灌饲小白鼠，空白对照组单纯灌饲５－Ｆｕ，正常对照组灌饲生理盐水，连续给药１０天后测定小鼠食量、体重及ＷＢＣ总数。结果：观察组小鼠日均食量（６８．９±１２．１）ｇ，体重为（２４．１±１．４）ｇ，ＷＢＣ总数（６．９±２．１）×１０９／Ｌ；与空白对照组比较有显著差异（Ｐ＜０．０１）。结论：得康口服液可以拮抗５－Ｆｕ引起的小鼠食量。Object:To observe the effects of Dekang Oral Liquid on the toxicity of 5 Fu such as weight lowering and the WBC count lowering of mice.Method:The small mice were infused with Dekang Oral Liquid and 5 Fu,the control group infused only with 5 Fu was also set up.Results:in the former group,the dietary of the mice was (68.9±12.1)g/d,weight (24.1±1.4)g,the average count of the WBC was (6.9±2.1)×10 9/L.The difference between the former group and the control group was significant (P<0.01).Conclusion:Dekang Oral Liquid have effects on the side effects of 5 Fu.

关 键 词：得康口服液 5-FU 食量 白细胞减少 实验研究 

分 类 号：R285.5[医药卫生—中药学]