川楝子化学成分的研究(Ⅰ)  

Chemical constituents of Toosendan Fructus(Ⅰ)

作　　者：周英[1] 王慧娟[1] 郭东贵[1] 王正林[1] 朱训[1] 胡芳[1] 李宙阳[1] 

机构地区：[1]贵州大学生命科学学院,贵州贵阳550025

出　　处：《中草药》2010年第9期1421-1423,共3页Chinese Traditional and Herbal Drugs

基　　金：贵州省科技厅国际合作项目[黔科合外G字(2008)700108];贵州省优秀科技教育人才专项基金(黔科教办200304);教育部春晖计划(Z2006-1-52014);贵州省教育厅自然科学类项目(黔科教2006304)

摘　　要：目的研究川楝Melia toosendan的果实的化学成分。方法采用柱色谱法对氯仿层进行分离纯化,并根据理化性质和光谱学数据对分离得到的化合物进行色谱结构鉴定。结果从川楝子氯仿层中分离得到6个化合物,分别鉴定为三十烷-15-醇(1)、豆甾醇(2)、β-谷甾醇(3)、Δ5,6-异川楝素(4)、壬酸十五醇酯(5)、己酸十三烷-(12-甲基)-2-醇酯(6)。结论化合物4为新化合物,命名为Δ5,6-异川楝素(Δ5,6-isotoosendanin),化合物1、2、5和6为首次从该植物中分离得到。Objective To study the chemical constituents of Toosendan Fructus,the fruit of Melia toosendan. Methods The chloroform layer was studied with chromatographic column separation method,and the chemical constituents were elucidated by their physicochemical properties and spectral data.ResultsSix compounds were isolated from the chloroform layer of Toosendan Fructus,the chemical structures of them were elucidated as： 15-triacontanol（1）,stigmasterol（2）,β-sitosterol（3）,Δ5,6-isotoosendanin（4）,pentadecane pelargonate（5）,and 2-（13-methyl）-tridecane caproate（6）.Conclusion Compound 4 is a new compound named Δ5,6-isotoosendanin,and compounds 1,2,5,and 6 are first isolated from Toosendan Fructus.

关 键 词：川楝子 楝科 Δ5 6-异川楝素 

分 类 号：R284.1[医药卫生—中药学]