紫花地丁化学成分研究  

Chemical constituents from Viola yedoensis

作　　者：徐金钟[1] 曾珊珊[1] 瞿海斌[1] 

机构地区：[1]浙江大学药学院,浙江杭州310058

出　　处：《中草药》2010年第9期1423-1425,共3页Chinese Traditional and Herbal Drugs

基　　金："重大新药创制"科技重大专项(2009ZX09313-036)

摘　　要：目的研究紫花地丁Viola yedoensis的化学成分。方法运用溶剂萃取、大孔树脂柱色谱、硅胶柱色谱以及反相HPLC等手段进行分离纯化,利用MS、NMR光谱进行结构鉴定。结果从紫花地丁中分离得到7个化合物,分别鉴定为金色酰胺醇酯(1)、金色酰胺醇(2)、金圣草素(3)、黑麦草内酯(loliolide,4)、异黑麦草内酯(isololiol-ide,5)、金合欢素-7-O-β-D-葡萄糖苷(6)、金合欢素-7-O-β-D-芹菜糖-(1→2)-β-D-葡萄糖苷(7)。结论除化合物4外,其他化合物均为首次从堇菜属植物中分离得到,其中化合物7作为天然产物为首次报道。Objective To study the chemical constituents of Viola yedoensis.Methods Solvent extraction,resin chromatography,silica gel column chromatography,and reverse phase preparative HPLC had been used in the isolation and separation of compounds from V.yedoensis.Based on the spectral data of MS and NMR,their structures were determined.Results Seven compounds were isolated and identified： aurantiamide acetate（1）,aurantiamide（2）,chrysoeriol（3）,loliolide（4）,isololiolide（5）,acacetin-7-O-β-D-glucoside（6）,and acacetin-7-O-βD-apiosyl-（1→2）-β-D-glucoside（7）.Conclusion Except compound 4,others are reported from the plants of Viola L.for the first time, and this is the first report for compound 7 as a natural product.

关 键 词：堇菜属 紫花地丁 金合欢素-7-O-β-D-芹菜糖-(1→2)-β-D-葡萄糖苷 

分 类 号：R284.1[医药卫生—中药学]