不完全川崎病患儿N端脑钠肽前体变化及其临床意义研究  

Change and significance of NT-proBNP in children with incomplete Kawasaki disease

作　　者：杨芳[1] 陈琅[1] 沈晓丽[2] 郭薇[3] 

机构地区：[1]福建医科大学省立临床学院儿科,福建福州350001 [2]福建医科大学省立临床学院免疫实验室,福建福州350001 [3]福建医科大学省立临床学院心脏彩超室,福建福州350001

出　　处：《中国实用儿科杂志》2010年第9期716-717,722,共3页Chinese Journal of Practical Pediatrics

基　　金：福建省卫生厅青年科研基金(2007-1-18)

摘　　要：目的观察N端脑钠肽前体(NT-proBNP)在小儿不完全川崎病中的变化,探讨其在不完全川崎病诊断中的价值。方法选取2007年3月至2009年2月福建医科大学省立临床学院儿科住院的36例典型川崎病(TKD)和20例不完全川崎病(IKD)患儿,分别检测其急性期及恢复期血浆NT-proBNP,并检测30例呼吸道感染患儿和30例健康儿童的血浆NT-proBNP,进行相互比较。同时对川崎病患儿急性期行心脏彩超检查。结果 TKD组和IKD组血浆NT-proBNP差异无统计学意义;TKD组和IKD组急性期血浆NT-proBNP明显高于恢复期和对照组(呼吸道感染组和健康组);IKD组合并冠脉病变显著高于TKD组。结论血浆NT-proBNP可作为一项早期诊断不完全川崎病的参考指标。Objective To observe the change of NT-proBNP in incomplete Kawasaki disease and study the value in the diagnosis of incomplete Kawasaki disease. Methods From Mar. 2007 to Feb. 2009 in department of paediatrics, Provincial Clinical Medical College of Fujian Medical University, we detected the acute- and restoration-stage plasma NT-proBNP level in 36 children with typical Kawasaki disease （TKD） and 20 with incomplete Kawasaki disease （IKD） respectively and 30 children with respiratory tract infection and 30 healthy children, and made a mutual comparison. Meanwhile ultrasound cardiogram examination was made in Kawasaki disease. Results There was no statistical significance in the difference of plasma NT-proBNP between TKD group and IKD group. Acute-stage plasma NT-preBNP in TKD group and in IKD group was clearly higher than that in restoration stage and control group （respiratory tract infection group and heahhy children group）. Coronary lesion in IKD group was significantly higher than that in TKD. Conelusion The plasma NT-proBNP can be used as a reference index in early diagnosis of IKD.

关 键 词：黏膜皮肤淋巴结综合征 N端-脑钠肽前体 川崎病 不完全 冠状动脉病变 

分 类 号：R72[医药卫生—儿科]