头孢吡肟致尿毒症透析患者神经系统不良反应2例  

Cefepime-induced neurological adverse reactions in two patients with uremia undergoing hemodialysis

作　　者：王志清[1] 

机构地区：[1]无锡市第三人民医院血液科,江苏无锡214041

出　　处：《药物不良反应杂志》2010年第4期284-286,共3页Adverse Drug Reactions Journal

摘　　要：2例尿毒症血液透析患者(女,76岁和男,56岁)因呼吸道感染分别给予头孢吡肟1.0g,1次/12h静脉滴注。女患者用药第5天出现精神萎靡、反应迟钝、烦躁不安伴随认知功能障碍、失语等,ECG呈弥漫性慢波。男患者用药第3天出现恶心、呕吐,烦躁、肌阵挛、言语迟缓、反应迟钝和精神错乱。此外,2例患者脑CT均未见明显改变。考虑患者神经系统不良反应与使用头孢吡肟有关。因此,停用头孢吡肟,继续行血液透析。随后患者的神经精神不良反应消失出院。Two patients （a woman aged 76 years and a man aged 56 years ） with uremia undergoing hemodialysis received an IV infusion of cefepime 1 g every 12 hours for respiratory tract infections,respectively. The woman developed listlessness,unresponsiveness,agitation,followed by agnosia and aphasia on day 5 of treatment,and ECG revealed diffuse slow waves. The man presented with nausea,vomiting,agitation,myocolonia,dysphasia,unresponsiveness,and mental confusion on day 3 of treatment. In addition,brain CT showed no marked change in both patients. Neurological adverse reactions were considered to be related to cefepime. Therefore,cefepime was discontinued and hemodialysis was continued. Subsequently,neurological and mental adverse reactions disappeared and both patients were discharged.

关 键 词：头孢吡肟 尿毒症 血液透析 不良反应 神经系统 

分 类 号：R692.5[医药卫生—泌尿科学]