唑吡坦致睡眠行为障碍3例  

Sleep behavior disorders induced by zolpidem in three patients

作　　者：邱畅[1] 江帆[2] 邝如意[3] 

机构地区：[1]广州市精神病医院临床药学室,广州510370 [2]广州市精神病医院睡眠障碍科,广州510370 [3]广州市精神病医院第九病区,广州510370

出　　处：《药物不良反应杂志》2010年第4期286-288,共3页Adverse Drug Reactions Journal

基　　金：广州市医药卫生科技资助项目(2008-YB-110)

摘　　要：3例女性患者因失眠口服唑吡坦后出现睡眠行为障碍。例1,56岁,口服唑吡坦10mg后入睡,1h后走入厨房,打开冰箱,随后进食,30min后自行回床入睡。次日晨对昨晚发生的事情毫无记忆。将唑吡坦减量至5mg,未再出现类似情况。例2,23岁,口服唑吡坦10mg后入睡,约2h后其同学收到1条来自患者手机的短信。次日患者对此事没有记忆。停用唑吡坦后未再出现上述症状。例3,28岁,口服唑吡坦15mg后入睡,10min后患者出现自言自语,并且不能识别其室友。次日晨患者对此事毫无记忆。停用唑吡坦,未再出现上述异常行为。Three patients with insomnia developed sleep behavior disorders after administration of zolpidem. Patient 1,a 56-year-old woman,fell asleep after taking zolpidem 10 mg. One hour later,she walked into kitchen,opened the door of refrigerator,and then ate the food. Thirty minutes later,she went to bed voluntarily. The next day,the patient had no memory of that event. The similar conditions did not recur after zolpidem was decreased to 5 mg. Patient 2,a 23-year-old woman,went to sleep after administration of zolpidem 10 mg. About two hours later,her classmate received one short message from the patient＇s mobile phone. The second day,she had no memory of that event. The above-mentioned symptoms did not recur after zolpidem discontinuation. Patient 3,a 28-year-old woman,fell asleep after receiving zolpidem 15 mg. Ten minutes later,the patient experienced soliloquy and cannot recognize her roommate. The next day,she had no memory of the event. The abnormal behavior was not recur after zolpidem discontinuation.

关 键 词：唑吡坦 不良反应 睡眠行为障碍 睡行症 

分 类 号：R595.3[医药卫生—内科学]