氟哌啶醇与丙咪嗪交互作用对成本效益决策的影响  

The Interaction of Haloperidol and Imipramine on Cost-benefit Decision Making in Rats

作　　者：崔睿思[1] 李新旺[1] 魏曙光[1] 焦晶晶[1] 朱小林[1] 

机构地区：[1]首都师范大学心理学系,北京市“学习与认知重点实验室”,北京100048

出　　处：《心理学报》2010年第9期946-954,共9页Acta Psychologica Sinica

基　　金：北京市重点建设学科-基础心理学资助

摘　　要：本实验采用T迷宫延迟奖赏模型研究多巴胺D2受体拮抗剂氟哌啶醇和5-羟色胺重摄取抑制剂丙咪嗪的交互作用对成本效益决策的影响,同时探讨了延迟时间对决策的影响。T迷宫两臂分别设置为低成本-低奖赏端和高成本-高奖赏端。实验结果发现:氟哌啶醇能够降低大鼠选择高成本-高奖赏端的次数,丙咪嗪则能够增加大鼠选择高成本-高奖赏端的次数;在同时注射这两种药物情况下,丙咪嗪能够抑制由氟哌啶醇引起的对低成本-低奖赏端的选择倾向。另外,实验发现,随延迟时间的增加大鼠选择高成本-高奖赏端的次数相对减少。由此可见,丙咪嗪能够反转由氟哌啶醇导致的对低成本-低奖赏端的选择倾向,这可能是由于细胞间5-羟色胺含量的升高部分反转了由多巴胺系统受损导致的行为倾向;延迟时间的改变可对决策倾向产生逆转,因此成本的支出即延迟时间也是影响成本效益决策的重要因素。Organisms constantly assess the cost and benefit of the possible future outcomes of their behavior and use the information to guide the future behavior, a process called cost-benefit decision making. The current study used a T-maze delayed reward procedure to examine the effects of the non-selective dopamine receptor antagonist haloperidol, and the norepinephrine/serotonin reuptake inhibitor imipramine on decision making （choice between a delayed high reward [HR] and an immediate low reward）, and how delay on access to the HR alters the decision making. Six groups of rats （n=8 per group） were treated with saline, haloperidol, imipramine （3, 8 or 10 mg/kg）, or a combination of haloperidol （0.2mg/kg） and imipramine （8mg/kg）. The experiment comprised three periods： initial training period during which animals had free access to the rewards located in both arms of the T-maze for each of the 10 daily trials; forced training period during which animals were allowed to have access to each of the two arms for the first two forced trials followed by 10 choice trials （access to both arms） with a delay imposed on the HR; and test period which was similar with the forced training period except that animals received drug treatment before the test session. Haloperidol decreased choice to HR when 15 or 30 s delay was applied to HR. In contrast, imipramine increased choice to HR. The decreased HR choice induced by haloperidol was reversed by imipramine. Increasing delay to HR decreased choice to HR. In conclusion, these data suggest that delay is an important factor for determining choice behavior, and that haloperidol and imipramine have opposing effects on decision making.

关 键 词：氟哌啶醇 丙咪嗪 成本效益 决策 延迟奖赏 

分 类 号：B845[哲学宗教—心理学]