趋化因子在丙型肝炎免疫发病机制中的作用  

Role of chemokines in the immunopathogenesis of hepatitis C

作　　者：周勤[1] 赵甫涛[1] 葛娅[1] 

机构地区：[1]广州军区武汉总医院感染科,武汉430070

出　　处：《传染病信息》2010年第4期253-256,共4页Infectious Disease Information

摘　　要：丙型肝炎(丙肝)感染后易于慢性化,与肝硬化及肝细胞癌的发生密切相关,目前尚无特效药物和疫苗。趋化因子是一类与炎症反应密切相关的小分子蛋白质,在机体抗病毒免疫中起重要作用。越来越多的研究表明,趋化因子及其受体与丙肝的持续感染、致病以及抗病毒效果等密切相关。因此,本文就趋化因子及其受体在丙肝免疫发病机制中的作用进行了简要的综述。Hepatitis C virus （HCV） infection leads to chronic liver disease easily, which may progress to cirrhosis and hepatocellular carcinoma. There is no specific drug or vaccine to prevent and treat HCV infection. Chemokines are a family of small chemotactic cytokines that are correlated with inflammation, and play an important role in antiviral immune responses. More and more researches demonstrate that chemokines and their receptors are closely associated with HCV persistent infection, pathogenesis and the efficacy of antiviral treatment. In this review, the authors focus on the role of chemokines and their receptors in the immunopathogenesis of chronic hepatitis C infection.

关 键 词：趋化因子类 受体 肝炎 丙型 慢性 病理过程 

分 类 号：R512.63[医药卫生—内科学]