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机构地区:[1]中南大学湘雅医院心内科,湖南省长沙市410008
出 处:《中国动脉硬化杂志》2010年第6期407-411,共5页Chinese Journal of Arteriosclerosis
摘 要:目的观察代谢综合征患者生长素水平的变化以及与炎症因子和内皮舒张功能的关系。方法代谢综合征患者131例,正常对照者132例,RIA法测定受试者体内生长素水平,ELISA法测量受试者体内炎症因子水平,比较不同组别间生长素水平,并分析生长素与内皮舒张功能和炎症因子的相关性,以及影响生长素水平的因素。结果代谢综合征组生长素水平比正常对照组低(P<0.01),低四分位生长素水平患者内皮舒张功能较高四分位生长素水平患者差(P<0.01);低四分位生长素水平患者肿瘤坏死因子α、白细胞介素8和单核细胞趋化蛋白1浓度比高四分位生长素水平患者高(P<0.01)。相关分析显示,生长素与内皮舒张功能呈正相关,与炎症因子浓度成负相关。多元回归分析显示,对生长素影响最大的是甘油三酯,其次是收缩压,然后是年龄。结论代谢综合征患者体内生长素水平下降,与内皮舒张功能呈正相关,与炎症因子浓度呈负相关,生长素可能改善内皮功能,降低炎症因子,阻止代谢综合征的发展。Aim To observe ghrelin level variation of metabolic syndrome patient and the relationship with in- flammatory factor. Methods According the definition of 2005 international diabetes mellitus association, the people were divided into metabolic syndrome ( MS ) group and control group. RIA method was used to measure ghrelin, and ELISA method was applied to measure inflammatory factor level. The different ghrelin level of the two groups was com- pared, and the relationship of ghrelin and endothelial relaxation function and inflammatory level were analyzed. Results The ghrelin levels of MS group were lower than that of control group (P 〈 0.001 ). The endothelial relaxation function of I st quartile ghrelin was lower than that of 4 th quartile ghrelin ; the inflammatory factor TNF-α, IL-8, MCP-1 concentrations of 1 st quartile ghrelin were higher than those of 4 th quartile; correlation analysis demonstrated that ghrelin level were positively related with endothelial relaxation function, and negatively related with the inflammatory functions ; multiple regression analysis suggested that the most influence ghrelin level was triglyceride, the next was systolic pressure , then age. Conclusions The ghrelin level of MS were decreased, and positively correlated with endothelial relaxation function, negatively correlated with inflammatory factor. Ghrelin may improve endothelial relaxation ruction, decrease inflammatory factor level, and prevent the development of MS.
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