p38MAPK在慢性鼻炎大鼠嗅黏膜中的表达及意义  

Expression of p38 signaling proteins in olfactory mucosa of rats with chronic rhinitis and its significance

作　　者：赵琳[1] 张向红[2] 曹辉[1] 梁建民[2] 孙斌[2] 王波涛[2] 

机构地区：[1]西安医学院附属医院耳鼻咽喉科,陕西西安710077 [2]西安交通大学第二医院耳鼻咽喉科,陕西西安710004

出　　处：《中国耳鼻咽喉颅底外科杂志》2010年第4期252-256,260,共6页Chinese Journal of Otorhinolaryngology-skull Base Surgery

基　　金：陕西省攻关项目;编号2005K12-G2(2)

摘　　要：目的研究慢性鼻炎大鼠嗅黏膜p38信号蛋白的表达,探讨慢性鼻炎嗅觉疾病的发病机制,为临床治疗慢性鼻炎鼻窦炎性嗅觉疾病提供理论依据。方法采用免疫组化S-P法测定20例慢性鼻炎大鼠嗅黏膜(慢性鼻炎组)和20例正常对照组大鼠嗅黏膜中p38信号蛋白的表达。结果慢性鼻炎组大鼠嗅黏膜上皮层和固有层嗅腺中p38丝裂原素活化蛋白激酶(p38mitogen-activated protein kinase,p38MAPK)的表达均高于正常对照组,差异有统计学意义(P<0.05)。慢性鼻炎组大鼠嗅黏膜上皮层和固有层嗅腺中磷酸化的p38丝裂原素活化蛋白激酶(Phospho-p38mitogen-activated protein kinase,Phospho-p38MAPK)的表达均高于正常对照组,差异有统计学意义(P<0.05)。结论 p38信号传导通路在慢性鼻炎大鼠嗅黏膜疾病的发生发展中具有重要的调控作用。Objective To study expression of p38 signaling proteins in olfactory mucosa of rats with chronic rhinitis,in order to elucidate the possible mechanism of olfactory diseases caused by chronic rhinitis,and to provide theoretical base for clinical treatment. Methods The expression of p38 signaling proteins in the olfactory mucosa of 20 rats with chronic rhinitis and that in 20 normal rats were studied by means of immunohistochemical S-P method. Results ① The expression of p38 mitogen-activated protein kinase （MAPK） in the olfactory mucosa of the rats with chronic rhinitis was higher than that in the normal rat with statistical significance （P0.05）. ② The expression of Phospho-p38MAPK in the olfactory mucosa of the rats with chronic rhinitis was higher than that in normal rats also with a significant difference （P0.05）. Conclusion The p38 signal transduction access plays an important regulatory role in the pathogenesis and development of olfactory mucosal diseases in rats with chronic rhinitis.

关 键 词：慢性鼻炎 嗅黏膜 p38丝裂原素活化蛋白激酶 信号传导通路 

分 类 号：R765.25[医药卫生—耳鼻咽喉科]