G3BP：一个潜在的肿瘤治疗靶点  

G3BP:a promising target for cancer therapy

作　　者：张浩[1] 邵荣光[1] 

机构地区：[1]中国医学科学院、北京协和医学院医药生物技术研究所,北京100050

出　　处：《药学学报》2010年第8期945-951,共7页Acta Pharmaceutica Sinica

基　　金：国家自然科学基金资助项目(30772583);国家重点基础研究发展计划(973计划)资助项目(2009CB521807);国家重大新药创制项目(2009ZX09301-003)

摘　　要：G3BP(RasGAP SH3domain binding protein)是一种RasGAP SH3结构域特异性结合蛋白,参与Ras下游信号通路,属于RNA结合蛋白家族。G3BP具有核酸内切酶、DNA解旋酶活性,能够诱导应急颗粒的形成,参与多种细胞生长、分化、凋亡和RNA代谢的信号通路。已经发现G3BP在多种肿瘤组织和细胞中高表达,并且与侵袭转移相关。由于G3BP与肿瘤细胞的多种生物学特性有关,因此G3BP有望成为一个肿瘤治疗的新靶点。G3BP （Ras-GTPase-activating protein SH3 domain binding protein）,a protein which binds to RasGAP SH3 domain,belongs to RNA-binding protein family,implicating in the downstream of Ras signaling. G3BP harbors the activities of endoribonuclease and DNA helicase,and can induce stress granules formation. G3BP plays a general role in the signal pathways of cell proliferation,differentiation,apoptosis and RNA metabolism. It has been shown to be over-expressed in a number of human malignancies and has a close relationship with tumor invasion and metastasis. Given that it has been implicated in several pathways that are known to be involved in cancer biology,G3BP may provide a new target for cancer therapy.

关 键 词：G3BP RASGAP RNA代谢 抗肿瘤药物 肿瘤治疗 

分 类 号：R963[医药卫生—微生物与生化药学]