丹参多酚酸盐对非ST段抬高急性冠脉综合征患者炎症因子的影响  

Effects of salvianolate on inflammatory factors in patients with non-ST-elevation acute coronary syndrome:a randomized controlled trial

作　　者：郭刚[1,2] 徐峰[2] 王冉[2] 李耀民[2] 于昕[2] 刘向群[2] 

机构地区：[1]山东中医药大学,山东济南250014 [2]山东大学齐鲁医院,山东济南250012

出　　处：《中国新药与临床杂志》2010年第8期599-601,共3页Chinese Journal of New Drugs and Clinical Remedies

基　　金：山东省科技攻关项目资助(2009GG20002019)

摘　　要：目的探讨丹参多酚酸盐对非ST段抬高急性冠脉综合征(ACS)患者炎症的影响。方法采用前瞻性随机对照研究,选取非ST段抬高ACS患者120例,随机分为2组:对照组60例,应用常规药物治疗;试验组60例,应用常规药物+丹参多酚酸盐200 mg·d-1;连用7 d。分别在用药前、用药后7 d检测血清高敏C反应蛋白(hs-CRP)和肿瘤坏死因子-α(TNF-α)浓度,用药后7 d行心脏彩超评价左室射血分数(LVEF)。结果用药前,2组基本临床资料、LVEF以及hs-CRP、TNF-α浓度均无显著差异(P>0.05)。用药后7 d,2组hs-CRP和TNF-α浓度均显著降低(P<0.01),试验组hs-CRP和TNF-α浓度较对照组下降非常显著(P<0.01);2组LVEF较用药前均改善(P<0.01),试验组LVEF显著高于对照组(P<0.05)。结论丹参多酚酸盐可改善非ST段抬高ACS患者LVEF,降低炎症因子水平。AIM To investigate the effects of salvianolate on inflammatory factors in patients with non- ST-elevation acute coronary syndrome （NSTEACS） in a single-center randomized control trial. METHODS One hundred and twenty patients with NSTEACS were randomly treated with traditional medicine with （trial group） or without 200 mg· d^-1 salvianolate （control group）. The serum levels of high sensitive C-reactive protein （hs- CRP） and tumor necrosis factor-α （TNF-α） and left ventricnlar ejection fraction （LVEF） were tested before and 7 days after the treatment. RESULTS There were no significant differences between the two groups in basic clinical data, hs-CRP, TNF-α and LVEF at the beginning of the study （P 〉 0.05）. Seven days after treatment, the levels of hs-CRP and TNF-oL decreased （P 〈 0.01） while LVEF increased （P 〈 0.01） compared with before treatment in both groups. In trial group, hs-CRP and TNF-ot levels were lower （P 〈 0.01 ） and LVEF was higher （P 〈 0.05） than that in the control group after treatment. CONCLUSION Salvianolate combined with conventional treatment could reduce the level of inflammatory factors and improve LVEF in patients with NSTEACS

关 键 词：丹参多酚酸盐 急性冠脉综合征 炎症 C反应蛋白质 肿瘤坏死因子Α 

分 类 号：R972.6[医药卫生—药品]