基于天津市医保数据的左氧氟沙星使用情况分析  

Analysis of clinical utilization of levofloxacin based on data from Tianjin Medical Insurance

作　　者：吴晶[1] 张玉哲[2] 郑亚明[1] 

机构地区：[1]天津大学药物科学与技术学院,天津300072 [2]沈阳药科大学工商管理学院,辽宁沈阳110016

出　　处：《中国新药与临床杂志》2010年第8期628-631,共4页Chinese Journal of New Drugs and Clinical Remedies

摘　　要：目的分析2007年天津市左氧氟沙星使用情况,为抗菌药合理使用和费用控制提供参考。方法随机抽取2007年天津市城镇参加医疗保险住院患者10%(共2.78万人次)作为样本,分析不同剂型左氧氟沙星的使用情况,规格与价格的关系,价格、数量和不同生产厂商的关系等。结果左氧氟沙星的静脉注射制剂占所有剂型用药金额的95%以上;大容量注射剂、小容量注射剂和粉针剂分别占静脉注射给药市场份额的71.84%、26.79%和1.37%。左氧氟沙星的原研制品和仿制品间以及不同仿制厂商间价格相差较大,同一生产厂商不同规格的药品换算成可比价格(元·0.1g-1)也有相当大的价格差距,最高的相差2倍;该药品单价和数量之间成显著正相关(P=0.0074),相关系数为0.6805,即价格越高的产品,使用数量越大。结论左氧氟沙星的临床使用不合理,存在较大调整空间,应通过政策调整以降低注射剂和高价药的使用比例。AIM To analysis the clinical utilization of levofloxacin based on data from Tianjin Medical Insurance in 2007 and to provide policy reference for the rational use and expenditure control of antibacterial agents. METHODS Ten percent of random inpatients samples from Tianjin Employee Basic Medical Insurance （27.8 thousands person-time） in 2007 were collected to analyze the proportions of different formulationes of levofloxacin, as well as the relationship between specification and price and the relationship among dosage, price, and manufacturers. RESULTS More than 95% of the total market share was taken up by i.v. injection; large volume parenteral solution, small volume parenteral solution, and powder for injection occupied 71.84%, 26.79%, and 1.37% of market share of i.v. injection, respectively. There were much price differences between the off-patent brand drugs and the generic drugs and among the different generic drug manufacturers. Even the drugs of the same factory in different specifications had different prices and the difference could as big as 2 times when the prices were conversed to the minimal unit of 0.1 g. It was found that the unit-price had a significantly positive correlation with the quantity （P = 0.007 4, correlation coefficient was 0.650 5） , which meant the higher the prices were, the more drugs were used. CONCLUSION There is irrational use of levofloxacin in clinical utilization of antibacterial agents and it can be greatly adjusted. The proportions of injection and highprice preparations can be reduced by necessary policy regulating.

关 键 词：左氧氟沙星 药物利用 经济学 药学 

分 类 号：R978.1[医药卫生—药品]