Th17细胞分化和功能调控研究的新进展  

Update on differentiation and functional regulation of Th17 cells

作　　者：潘涛[1] 张伟[2] 陈长水[1] 

机构地区：[1]华南师范大学激光生命科学研究所教育部重点实验室,广州510631 [2]国家生物医学分析中心,北京100850

出　　处：《免疫学杂志》2010年第9期819-822,826,共5页Immunological Journal

基　　金：总后科研"115"计划课题(08G168)

摘　　要：辅助性T细胞家族新成员Th17细胞亚群在机体促炎症反应机制中发挥重要功能,尤其是促进多种自身免疫疾病发病的重要效应细胞;因此该细胞亚群的分化和免疫功能调控研究具有重要的基础和临床医学价值。本文就影响Th17细胞分化的细胞因子、转录因子、芳香烃受体、视黄酸和溴氯哌喹酮等的最新进展进行了简要综述,以期加深对Th17细胞分化和免疫功能调控机制的了解,拓宽进一步深入研究的视野和思路。T-helper 17 （Th17） cells,a recently identified T helper subset,play crucial roles in pro-inflammatory response and act as important effector T cells in various autoimmune diseases. Thus,the research on regulation of Th17 differentiation and immunologic function is of great importance for theoretical and clinical medicine. The latest advances in this field will be summarized including cytokines,transcription factors,aryl hydrocarbon receptor,retinoid,acid and halofuginone. Emerging data regarding Th17 cells suggest that the regulation modes of Th17 cells differentiation and immunologic function are not unique,but varied according to different physiological or pathological conditions.

关 键 词：T细胞辅助细胞17 白介素6 转录生长因子β 信号传导及转录活化因子3 视黄酸受体相关的孤儿受体γt 芳香烃受体 视黄酸 溴氯哌喹酮 

分 类 号：R392.12[医药卫生—免疫学]