缬草西番莲镇静催眠作用的研究  

Hypnosedative effects of extracts from valeriana officinalis and passiflora incarnata

作　　者：张劲鹏[1] 韩光亭[2] 张劲峰[3] 张天民[4] 宫英[2] 顾天鸽[5] 王雪鹤[3] 

机构地区：[1]右江民族医学院神经精神病学教研室,广西百色533000 [2]青岛大学国家重点实验室培育基地,山东青岛266071 [3]青岛大学医学院松山医院泌尿外科,山东青岛266021 [4]滕州市工人医院外科,山东滕州277500 [5]滕州市中医医院内科,山东滕州277500

出　　处：《广州医学院学报》2010年第2期17-19,共3页Academic Journal of Guangzhou Medical College

基　　金：广西壮族自治区卫生厅自筹经费科研课题（NO.E2006298）;右江民族医学院项目（NO.200673）.

摘　　要：目的：研究不同剂量缬草西番莲水提物的镇静催眠作用并确定其活性部位及分析其有效剂量。方法：观察不同剂量缬草西番莲水提物对小鼠自主活动的影响以及直接镇静催眠作用、及与戊巴比妥钠的协同作用。结果：缬草西番莲水提物能显著增加小鼠睡眠率，减少小鼠的自主活动次数；延长阈上剂量戊巴比妥钠睡眠时间，缩短入睡潜伏期，显著增加阈下剂量戊巴比妥钠小鼠睡眠率。结论：缬草西番莲水提物具有良好的镇静催眠作用，是其镇静催眠活性的有效组分。Objective：To study the active components, hypnosedative effects and optimal effective dose of water extracts from Valeriana officinalis and Passiflora incarnata. Methods： Different doses of water extracts of Valeriana offieinalis and Passiflora incarnata were examined for their effects on voluntary activities, hypnosedative actions and synergism with pentobarbital sodium in Kunming mice. Results： The water extracts markedly inhibited the frequency of voluntary activities, prolonged the sleeping time induced by suprathreshold dosage of sodium pentobarbital, shortened the latency of sleeping, and remarkably increased the rate of successful sleeping in mice receiving infrathreshold dosage of pentobarbital sodium. Conclusion： The water extracts may be bioactive components of Valeriana officinalis and Passiflora incarnata with satisfactory hypnosedative effects.

关 键 词：缬草 西番莲 镇静 催眠 

分 类 号：R285.5[医药卫生—中药学]