急性脑出血患者血清中胶原纤维酸性蛋白含量变化及其临床意义  

The Change of Serum Concentration of Glial Fibrillary Acidic Protein and its Clinical Significance in Patients with Acute Intracerebrai Hemorrhage

作　　者：刘振国[1] 王晶[2] 刘伟亮[1] 

机构地区：[1]潍坊医学院附属潍坊市人民医院麻醉科,山东潍坊261041 [2]解放军第八十九医院麻醉科

出　　处：《潍坊医学院学报》2010年第3期213-215,共3页Acta Academiae Medicinae Weifang

摘　　要：目的观察急性脑出血患者血清中胶原纤维酸性蛋白（GFAP）含量及其临床意义。方法采用酶联免疫吸附法（ELISA）测定33例脑出血患者发病后12h内及30名健康人（正常对照组）血清GFAP含量，分析脑出血患者GFAP含量与神经系统功能缺损程度评分（NIHSS）及预后之间的关系。结果脑出血组患者血清GFAP含量高于正常对照组（P〈0．01）；血清GFAP含量与NIHSS（r=0．49，P〈0．01）及预后（r=0．70，P〈0．01）呈正相关；应用ROC曲线分析，以血清GFAP浓度5．58ng／L为标准评估预后，敏感度为0．89，特异度为0．79。结论脑出血后血清GFAP含量增高，在一定程度上反映了患者的病情程度，有助于早期预后的评估。Objective To observe the change of serum concentration and clinical significance of glial fibrillary acidic protein （ GFAP ） in patients with acute intracerebral hemorrhage （ ICH ）. Methods A total of 33 patients were involved in this study. GFAP concentration in the serum of 33 patients on admission（ 〈 12hours） and 30 healthy people were detected by enzyme linked immunosorbent assay （ ELISA ） , and the relation between GFAP concentration and degree of neurologic impairment （ NIHSS ） and prognosis were analyzed. Results The GFAP level of patients was higher than that of the control group（ P 〈0.01 ） ;The serum level of GFAP has positive correlation with NIHSS（ r =0.49 ,P 〈0.01 ） and MRS（ r =0.70,P 〈0.01） ;Using receiver operating characteristic curve（ ROC） analysis,a cut off point of 5.58ng/ L provided a sensitivity of O. 89 and a specificity of 0.79 for the identification of prognosis. Conclusion GFAP level is Increased after acute ICH,and is associated with the severity and prognosis of the patients with ICH.

关 键 词：生物标记 脑出血 胶原纤维酸性蛋白 预后 

分 类 号：R651.15[医药卫生—外科学]