慢性阻塞性肺疾病急性加重期合并肝损害临床分析  

Acute exacerbation and liver function impairment of chronic obstructive pulmonary disease patients:a clinical analysis

作　　者：余贻汉[1] 张继先[2] 屈银宗[1] 缪胜菊[2] 郭玉飞[1] 汪毅[1] 

机构地区：[1]湖北省新华医院消化科,武汉市430015 [2]湖北省新华医院呼吸科,武汉市430015

出　　处：《中华老年多器官疾病杂志》2010年第4期346-348,共3页Chinese Journal of Multiple Organ Diseases in the Elderly

摘　　要：目的分析慢性阻塞性肺疾病(COPD)急性加重期合并肝损害患者的临床特点,并分析保肝治疗对其预后的影响。方法入选患者均给予基础治疗并分为3组:56例COPD并发肝损害患者给予护肝治疗(A组),42例COPD并发肝损害患者未给予保肝治疗(B组),68例COPD无肝损害患者未给予保肝治疗(C组)。比较3组的临床症状、实验室结果、住院天数、住院费用及临床转归。结果 A组和B组的临床症状、住院费用、住院天数均高于C组,预后比C组差。A组的住院费用比B组高〔(9534±326)vs(7864±265)元〕。而住院天数〔(25±6)vs(25±6)d〕、肝功能转归和死亡率(17.3%vs16.8%)两组无差异。结论 COPD患者并发肝损害会延长住院天数、增加住院费用、增加死亡率,但护肝治疗对转归无显著影响。Objective To analyze the clinical characteristics of chronic obstructive pulmonary diseases （COPD） patients with acute exacerbation and liver function impairment and the influence of the liver-protective therapy on the prognosis of the patients. Methods All selected patients received basic therapy, and were divided into 3 groups. In group A, 56 COPD patients with liver function impairment received liver-protective therapy. In group B, 42 COPD patients with liver function impairment received no liver-protective therapy. In group C, 68 COPD patients without liver function impairment received no liver-protective therapy. The clinical symptoms, the laboratory test results, hospitalization duration, hospitalization cost, and the clinical outcome were compared among three groups. Results Compared with group C, the patients in group A and B displayed a worse clinical outcome, more severe clinical symptoms, higher hospitalization cost, and longer hospitalization duration. The hospitalization cost was higher in group A than in group B [（9 534±326） vs （7 864±265） RMB yuan）], while hospitalization duration [（25±6） vs （25±6） d], recovery of liver function, mortality （17. 3% vs 16. 8%） had no significant difference between group A and B. Conclusion Liver function impairment in COPD patient with acute exacerbation extends hospitalization duration, increases hospitalization cost, and raises the patients＇ mortality. However, liver-protective therapy exerts no effect on the prognosis of the patients

关 键 词：肺疾病 慢性阻塞性 肝功能 缺氧 预后 

分 类 号：R563[医药卫生—呼吸系统]