原发性高血压患者动态动脉硬化指数与颈动脉粥样硬化的相关性  

Correlations of Ambulatory Arterial Stiffness Index and Carotid Atherosclerosis in Primary Hypertension Patients

作　　者：刘艳[1] 曹桂莲[2] 陈爱芳[3] 

机构地区：[1]泰山医学院附属医院心内科,山东省泰安市271000 [2]泰山医学院附属医院心电图室,山东省泰安市271000 [3]泰山医学院附属医院超声科,山东省泰安市271000

出　　处：《中国动脉硬化杂志》2010年第7期563-565,共3页Chinese Journal of Arteriosclerosis

摘　　要：目的探讨原发性高血压患者动态动脉硬化指数与颈动脉粥样硬化的相关性。方法 124例原发性高血压患者和70例健康对照者,根据颈动脉超声检查,将原发性高血压患者按内膜中膜厚度≥0.9 mm者分为颈动脉硬化组,内膜中膜厚度<0.9 mm者分为无颈动脉硬化组。通过24 h动态血压监测,分析血压参数特点,计算动态动脉硬化指数。结果原发性高血压患者颈动脉内膜中膜厚度、颈动脉斑块积分明显高于健康对照者(1.178±0.214 mm和0.806±0.356比3.17±2.44 mm和1.02±1.51,P<0.01),原发性高血压患者和健康对照者动态动脉硬化指数值分别为0.56±0.14和0.41±0.12(P<0.01);颈动脉硬化组和无颈动脉硬化组动态动脉硬化指数分别为0.59±0.12和0.50±0.11(P<0.05),动态动脉硬化指数与内膜中膜厚度呈正相关(r=0.325,P<0.01)。结论原发性高血压患者动态动脉硬化指数与颈动脉粥样硬化关系密切。Aim To evaluate the correlation of ambulatory arterial stiffness index（AASI） and carotid atherosclerosis in primary hypertension patients. Methods 124 primary hypertension patients and 70 healthy people were selected.The carotid artery intima-media thickness（IMT） were determined by ultrasonography.Primary hypertension patients were divided into two groups according to IMT： IMT≥0.9 mm as carotid atherosclerosis and IMT0.9 mm as non carotid atherosclerosis.Twenty-four-hour ambulatory blood pressure monitoring（ABPM） was performed and the blood pressure parameters were analyzed to calculate AASI. Results IMT and plaque score in primary hypertension group was higher than that in healthy control group（1.178±0.214 mm and 0.806±0.356 vs 3.17±2.44 mm and 1.02±1.51,P0.01）.AASI in primary hypertension group was higher than that in healthy control group（0.56±0.14 and 0.41±0.12,P0.01）.And so was in carotid atherosclerosis group and non carotid atherosclerosis group（0.59±0.12 and 0.50 ±0.11,P0.05）.AASI were correlated with IMT positively（r=0.325,P0.01）. Conclusion AASI was closely related to carotid atherosclerosis in primary hypertension patients.

关 键 词：原发性高血压 动脉粥样硬化 动态动脉硬化指数 内膜中膜厚度 

分 类 号：R5[医药卫生—内科学]