高胆固醇血症血液流变性的研究  

THE STUDY OF BLOOD RHEOLOGY AND BIOCHEMICAL BASIS IS EXPERIMENTAL HYPERCHOLESTEROLEMIC RABBITS

作　　者：金永娟[1] 高世嘉[1] 董松 朱文云[1] 

机构地区：[1]中国医学科学院血液学研究所

出　　处：《生物物理学报》1990年第2期191-196,共6页Acta Biophysica Sinica

基　　金：国家自然科学基金资助项目

摘　　要：对实验性高胆固醇血症家兔血液流变性、红细胞流变性、红细胞膜脂分析以及与血清胆固醇浓度之间关系的研究指出随血清胆固醇浓度升高,全血表观粘度和血浆粘度升高,红细胞(?)积和(?)降低.进一步分析表明,随血清胆固醇浓度升高,红细胞膜中胆固醇Ch含量增加,引起膜胆固醇和磷脂(P1)的克分子比(Ch,P1)升高,膜的荧光偏振度(P)增大,表示红细胞流动性降低,而对照组各项指标在实验过程中保持稳定.In this study we have investigated the reletionship between rheological prop-ecties of blood and serum cholesterol concentration(SCH in the experimental hypercholesterolemic rabbits. The results indicate that rheological properties of blood, mole ratio of cholesterol to phospholipid(Ch P1) in RBC membrane and SCH are kept stable in control during this experiment In hypercholeterolemic, the SCH is elevated sharply with feeding time, whole blood and plasma viscosity are significantly increased( P<0.01), RBC membrane Ch P1 increased by 23%, RBC deformability decreased by 27%, and fluorescence polarization(P) of RBC membrane decreased by 31% after 12 weeks.The correlation analysis suggests that membrane Ch P1 is positive correlation with SCH r= 0.983. P<0.02 merriorane fluorescence polarization P is post tive correlation with membrane Ch P1=0.99-.P <0.01. RBC deformability is negative correlation with membrane fluorescence polanzation P r=-0.999,P<0.01.

关 键 词：高胆固醇轿症 血液流变性 生物物理 

分 类 号：R589.202[医药卫生—内分泌]