黄体生成素受体rs61996318基因多态性与多囊卵巢综合征的相关性研究  

The relationship between the polymorphisms of the Luteinizing hormone receptor(LHR) and polycystic ovary syndrome

作　　者：马延敏[1] 王树玉[1] 张小为[2] 张秋芳[2] 傅莉[2] 张雪[2] 涂彬彬[2] 乔杰[2] 

机构地区：[1]首都医科大学附属北京妇产医院生殖中心,100026 [2]北京大学第三医院妇产科,100191

出　　处：《中国优生与遗传杂志》2010年第9期25-26,共2页Chinese Journal of Birth Health & Heredity

摘　　要：目的探讨黄体生成素受体(Luteinizing hormone receptor,LHR)基因rs61996318多态性与PCOS的相关性。方法应用聚合酶链反应-限制性片段长度多态性(Polymerase chain reaction-restriction fragment length polymorphism PCR-RFLP)方法对北京大学第三医院及北京妇产医院生殖中心门诊患者进行LHR基因rs61996318多态性进行检测,并通过基因测序证实。结果 RFLP检测未发现rs61996318位点突变。通过基因测序证实无突变。结论 LHCGR的SNP位点rs61996318是中国人稳定的多态位点,与PCOS的发病无关。Objective：To investigate the relationship between the polymorphisms of the luteinizing hormone receptor（LHR） and polycystic ovary syndrome（PCOS） women in China.Methods：The polymorphism of LHR was detected by restriction fragment length polymorphism-polymerase chain reaction（PCR-RFLP） in 428 PCOS women and 280 control women.Gene sequence was detected in part of patients.Results：708 women,including 428 PCOS and 280 controls were detected using Restriction fragment length polymorphism-polymerase chain reaction.No mutation of SNP rs61996318 was detected in all the patients.Conclusion：SNP rs61996318 was a stable polymorphism site in Chinese women.The SNP has no relationship with the etiology of PCOS.

关 键 词：多囊卵巢综合征 单核苷酸多态性 黄体生成素 聚合酶链反应 限制性片段长度多态性基因 

分 类 号：R711.75[医药卫生—妇产科学]