心房颤动射频消融术前后心肌生化标志物及炎性因子的变化  

Investigation of the Changes of cTNI,CK,CK-MB and hs-CRP in Patients with Atrial Fibrillation and RFCA

作　　者：常海明[1] 朱建国[2] 那开宪[2] 

机构地区：[1]北京怀柔区妇幼保健院内科,北京101400 [2]首都医科大学附属北京朝阳医院心脏中心,北京100020

出　　处：《中国医药导刊》2010年第8期1299-1300,共2页Chinese Journal of Medicinal Guide

摘　　要：目的:观察Carto系统引导下心房颤动(AF)射频消融术(RFCA)前后患者心肌生化标记物心肌肌钙蛋白I(cTNI)、肌酸激酶(CK)、肌酸激酶同功酶(CK-MB)及炎性因子高敏C反应蛋白(hs-CRP)的变化及变化趋势。方法:选择在Carto系统引导下行AF RFCA治疗患者20例,于射频消融术前、术后4～6h、术后24h及72h采集肘静脉血,分别测定cTNI、CK、CK-MB及hs-CRP的值并与治疗前进行比较。结果:20例患者均未出现并发症,cTNI术后较术前明显升高,结果有显著性差异(P<0.01);术后24小时升高达峰值,72h后较前明显下降,但仍高于术前基础水平(P<0.01)。射频消融术后CK-MB较术前明显升高(P<0.05),术后72h同术前比较无明显差异(P>0.05)。术后hs-CPR逐渐升高,至72h仍未达峰值,与基础值比较有显著性差异。结论:cTNI、CK、CK-MB在AF射频消融术后出现显著升高,可引起心肌损伤。AF射频消融术后hs-CRP明显升高可引起机体明显的炎症反应。[ABSTRACT] Objective：To investigate the changes of cTN1, CK, CK-MB and hs-CRP in patients with atrial fibrillation radiofrequency catheter ablation. Methods： In 20 patients undergoing RFCA using Carto system for atrial fibrillation, cTNI, CK-MB, CK, hs-CRP levels were measured before, 4-6h, 24h, 72h after RFCA. Results：20 patients with RFCA had no complications, cTN1 level was Significantly increased after operation（P〈0.01）. The level of cTN1 reached to the highest degree at 24h, decreased at 72h but still greater than the level at baseline. CK-MB level was greater than that of baseline（P〈0.05）. The level of CK-MB was similar at 72h after RFCA with baseline（P〉0.05）. The level of hs-CRP increased gradually after the procedure of RFCA. The level at 72h after RFCA was greater than that of baseline significantly （P〈0.01）. Conclusions： The procedure of RFCA can induce the cardiac injury obviously and induce the inflammation.

关 键 词：心房颤动 射频消融术 心肌损伤 炎症因子 

分 类 号：R541.7[医药卫生—心血管疾病]