毛细管GC法测定格列齐特片和格列齐特片(Ⅱ)的含量  

Content determination of gliclazide tablets and gliclazide tablets( Ⅱ) by capillary GC

作　　者：韩学静[1] 王熳[1] 杜增辉[1] 

机构地区：[1]河北省药品检验所,石家庄050011

出　　处：《中国实用医药》2010年第26期7-8,共2页China Practical Medicine

摘　　要：目的建立毛细管GC法测定格列齐特片和格列齐特片(Ⅱ)的含量。方法以正十四烷为内标,采用DB-624毛细管柱,FID检测器,甲醇为溶剂。结果格列齐特在0.15～1.5mg/ml浓度范围内线性关系良好,线性方程R=1.251c-0.024,r=0.9995(n=6)。平均回收率为99.49%和99.61%,RSD为0.65%和0.52%。结论本法可用于测定格列齐特片和格列齐特片(Ⅱ)的含量,方法灵敏、简便、准确。Objective To establish a capillary GC method for the determination of Gliclazide Tablets and Gliclazide Tablets（ Ⅱ） . Methods A DB-624 capillary column was used with FID as detector and methanol as the solvent using n-tetradecane as the internal standard. Results The linear range of the calibration curve of Gliclazide were 0. 15 ～ 1. 5 mg/ml（ r = 0. 9995） ,the average recevery was 99. 49% and 99. 61% . The relative standard deviations（ n = 6） were 0. 65% and 0. 52% . Conclusion It can be used to determination the content of the Gliclazide Tablets and Gliclazide Tablets（ Ⅱ） ,The method is simply,sensitive,accurate and reliable.

关 键 词：格列齐特片 格列齐特片(Ⅱ) 毛细管气相色谱 测定 

分 类 号：R927[医药卫生—药学]