2型糖尿病患者超敏C反应蛋白和白细胞介素6的应用研究  

Application study of high sensitivity C-Reactive protein and interlukin-6 in type 2 diabete

作　　者：宋燕[1] 于景云[1] 张凤华[2] 

机构地区：[1]辽宁省大连大学附属新华医院检验科,116002 [2]大连医科大学附属第一医院

出　　处：《中国实用医药》2010年第26期20-21,共2页China Practical Medicine

摘　　要：目的探讨血清超敏C反应蛋白(hs-CRP)和血清白细胞介素6(IL-6)在糖尿病并发血管病变的临床价值。方法采用日立7180全自动生化分析仪及ELISA双抗体夹心法对98例2型糖尿病患者(其中血管病变组55例,非血管病变组43例)及40名健康对照的hs-CRP、IL-6、GSB、TC、TC/HDL-C、TC/LDL-C进行测定。结果 98例2型糖尿病患者hs-CRP、IL-6比40名健康对照明显升高(P<0.001),2型糖尿病合并血管病变组(A组)hs-CRP、IL-6比2型糖尿病非合并血管病变组(B组)明显升高(P<0.001),且与GSB、TC、TC/HDL-C、TC/LDL-C正相关。结论糖尿病患者血清IL-6参与诱导肝急性时相蛋白(CRP)的合成,并共同参与糖尿病血管病变的病理过程。Objective To discussthe clinical value of highsensitivity C-Reactive protein（ hs-CRP） and interlukin-6（ IL-6） on patient of diabetes with microangiopathy. Methods Serum hs-CRP、IL-6、GSB、TC、TC/ HDL-C、TC/LDL-C in 98 patients of T2DM（ 55 diabetes with microangiopathy and 43 diabetes without microangiopathy） and 40 health controls were measured by HITACHI7180 and ELISA. Results The serum hs-CRP、IL6 in the 98 patients of T2DM was higher than those of 40 health controls（ （ P〈0. 001） . The serum hs-CRP、IL6 in 55 diabetes with microangiopathy was higher than those of a 43 diabetes without microangiopathy,hs-CRP、 IL-6 is positively with GSB、TC、TC/HDL-C、TC/LDL-C. Conclusion For diabetes serum IL-6 plays roles in inducing the synthetic of CRP when there is an acute liver and also plays roles in the pathologic process diabetes microangiopathy.

关 键 词：C反应蛋白 白细胞介素6 2型糖尿病 血管病变 

分 类 号：R587.1[医药卫生—内分泌]