再生复血汤治疗慢性再生障碍性贫血的临床研究  

Clinical Study of Zaishengfuxue Medicinal Decoction Treating Chronic Aplastic Anemia

作　　者：袁通春[1] 江劲波[2] 何群[3] 

机构地区：[1]上海交通大学医学院苏州九龙医院,江苏苏州215021 [2]湖南中医药大学附属第一医院血液科,湖南长沙410007 [3]中南大学湘雅医院血液科,湖南长沙410008

出　　处：《辽宁中医杂志》2010年第9期1718-1721,共4页Liaoning Journal of Traditional Chinese Medicine

摘　　要：目的:探讨再生复血汤治疗脾肾两虚型慢性再生障碍性贫血的临床疗效及分析其可能的作用机制。方法:选择40例脾肾两虚型慢性再障患者,随机分为中药治疗组(A组)对照组(B组),分别予再生复血汤、安雄+左旋咪唑治疗6个月,对血象、骨髓象、中医征候疗效、有效率、T细胞亚群变化等进行比较。结果:A组总有效率为80.0%,B组为60.0%,两组比较差异无统计学意义(P>0.05)。中医证候改善率A组为90.0%,B组为60.0%,两组比较差异显著(P<0.05)。A组与B组治疗后Hb、WBC、RBC、GR、Plt、Ret均有明显上升,LYM明显下降,两组分别与治疗前比较均有统计学意义(P<0.05)。治疗后血象变化两组比较差异均无统计学意义(P>0.05)。骨髓增生程度均有增高,A组治疗前后比较差异有统计学意义;B组前后比较无统计学意义。两组治疗后比较差异有统计学意义(P<0.05)。T细胞亚群治疗前CD4+降低,CD8+升高,CD4+/CD8+下降,治疗后CD4+升高,CD8+降低,CD4+/CD8+比值增大。两组组内治疗前后比较差异均有统计学意义(P<0.05),组间比较差异无统计学意义(P>0.05)。A组未发现明显毒副不良反应。结论:再生复血汤治疗脾肾两虚型慢性再障有确切疗效,疗效与安雄+左旋咪唑相当,安全性好。对再障患者有一定的免疫调节和刺激骨髓增生作用。Objective：To discuss the clinical curate effect and study the mechanism on patient with Chronic Aplastic Anemia by using Zaishengfuxue Medicinal decoction. Methods：40 cases of patients with CAA were selected and divided into two groups randomly,as the traditional Chinese Medicine treatment group（ n = 20） with Zaishengfuxue decoction ,the Western Medicine control group（ n = 20） with Andriol added Levamisole. All the groups were treated for 6 months. The clinical curative effect,Chinese medical syndromes,peripheral blood hemogram and myelogram,symptoms,effect rate,T-cell subsets were observed. Moreove,all of above were compared between treatment and control group. Results：The total effective rate of Zaishengfuxue treating CAA which asthenia of both the spleen and kidney was 80. 0% ,the control group was 60. 0%. The difference of two groups has no signifi-cance（ P 0. 05）. Chinese medical syndromes improvement rate was 90. 0% ,the control group was 60. 0%. The difference of two groups wew statistically significant（ P 0. 05）. The results showed that hemogram,CD 4＋ ,Chinese medical syndromes and curative effect were significantly enhanced both in treatment and control group. Mylogram proliferation was significantly enhanced in treatment group. As a result,the therapecutic group as good as the control group about myelogram curative effect. It made better to the therapecutic group than to the control group in Chinese medical syndromes. The recovery of the levels of bone marrow in the Zaishengfucue group was more obvious than that before treatment. Before treatment,peripheral blood T cell subsets CD 4＋ depressed and CD 8＋ increased,CD 4＋ /CD 8＋ depressed. The information opposite after treatment. The difference of two groups has no significance after treatment. Furthermore,it is clear that the treatment group has fewer toxic and side-effect. Conclusion：Zaishengfuxue Medicinal decoction is efficacious in treating chronic aplastic anemia with asthenia of both the spleen and kidney. It can i

关 键 词：再生障碍性贫血 慢性 脾肾两虚型 再生复血汤 安雄 左旋咪唑 

分 类 号：R556.5[医药卫生—血液循环系统疾病]