冠心病心绞痛病证结合方证对应的临床研究  

Clinical Study of Prescriptions Corresponding to Syndrome in Treating Angina pectoris based on Combination of Disease and Syndrome

作　　者：孙晓伟[1,2] 王阶[2] 褚福永[2] 邢雁伟[2] 王师菡[2] 李志忠[3] 

机构地区：[1]北京中医药大学东直门医院,北京100700 [2]中国中医科学院广安门医院,北京100053 [3]首都医科大学附属安贞医院,北京100029

出　　处：《辽宁中医杂志》2010年第9期1739-1741,共3页Liaoning Journal of Traditional Chinese Medicine

基　　金：国家自然科学基金项目(90709048)

摘　　要：目的:探讨方证对应的临床疗效,在病证结合的基础上观察冠心病心绞痛方证对应的临床疗效。方法:88例经冠脉造影明确诊断的冠心病心绞痛患者,血瘀证组、气阴两虚证组各44例,按照随机、双盲、双模拟的设计方法,以血府逐瘀胶囊和生脉胶囊分别给予方证对应与方证不对应干预治疗4周。观察每组患者的心绞痛疗效、中医证候疗效、心电图改善及相关理化指标的变化。结果:治疗后心绞痛总有效率方面,两证各自及总体方证对应组与不对应组比较具有统计学意义(P<0.05);中医证候疗效方面,两组比较具有统计学意义(P<0.05);实验室指标方面;血瘀证方证对应组在降低hs-CRP、Hcy、ET、MPO、MMP9优于方证不对应组(P<0.05),气阴两虚证组间比较无差异;两组治疗后在BNP、PAF、PAG的改善方面无统计学意义(P>0.05)。结论:临床疗效与方证对应的程度密切相关,方证对应在改善冠心病心绞痛患者的心绞痛疗效、中医证候疗效及部分理化指标方面优于方证不对应组,提示方证对应取得疗效可能有其作用靶点。Objective：To explore the clinical effect of Prescriptions Corresponding to Syndrome in treating angina pectoris on the basis of Combination of Disease and Syndrome,and disclose the mechanism of Prescriptions Corresponding to Syndrome. Meth-ods：88 patients with angina pectoris（ AP） diagnosed by coronary angiography,including blood stasis（ 44 patients） and deficiency of both qi and yin（ 44 patients） respectively,were divided in two groups to abide by randomizd,double-blind,double-dummy design. Prescriptions Corresponding to Syndrome and Prescriptions non Corresponding to Syndrome interved those patients using Xuefu Zhuyu Capsule and Shengmai Capsule. Clinical effect of AP,syndrome,electrocardiography（ ECG） ,related laboratory indi-cator were evaluated after. Results：Prescriptions Corresponding to Syndrome group was superior than non Corresponding group in both total effective power and ameliorating syndrome（ P 0. 05）. After treatment,the improvement on hs-CRP、Hcy、ET、MPO、MMP9 in blood stasis group using Prescriptions Corresponding to Syndrome were better than not（ P 0. 05） ,but there was no similar result in deficiency of both qi and yin. There were no significant difference on amelioration of ECG、BNP、PAF、PAG between two groups（ P 0. 05）. Conclusion：Prescriptions Corresponding to Syndrome is superior than not on the improvement of AP,syndrome,partial laboratory indicator,which disclose there would be action target when showing better clinical effect.

关 键 词：冠心病心绞痛 病证结合 方证对应 

分 类 号：R541.4[医药卫生—心血管疾病]