降糖明目汤对BDR大鼠的抵抗素与NF-κB影响的实验研究  

Experimental Study of Jiangtangmingmu Formula to BDR model Rabbits'Resistin and NF-κB

作　　者：纪云西[1] 蒋历[2] 宋春晖[2] 吴大力[3] 易志彪[1] 陈大舜[2] 

机构地区：[1]广州中医药大学,广东广州510405 [2]湖南中医药大学,湖南长沙410007 [3]广西中医学院,广西南宁530001

出　　处：《辽宁中医杂志》2010年第9期1818-1820,共3页Liaoning Journal of Traditional Chinese Medicine

摘　　要：目的:观察降糖明目汤对背景期糖尿病视网膜病变(BDR)模型兔的抵抗素、NF-κB的影响。方法:BDR模型兔随机分为模型组、降糖明目汤治疗组和西药导升明对照组,检测血清抵抗素、胰腺组织NF-κBp65表达,并与正常组比较。结果:模型组实验兔血清抵抗素浓度明显升高,与中药治疗组、西药对照组和空白对照组三者比较有极显著性差异(P<0.01);但中药治疗组、西药对照组和空白对照组三者之间比较均无显著性差异(P>0.05)。模型组实验兔胰腺组织NF-κBp65强表达,与正常组、中药治疗组比较,有极显著差异(P<0.01),与西药对照组比较无显著性差异(P>0.05);中药治疗组与西药对照组比较有显著性差异(P<0.05)。中药治疗组与正常组比较无显著性差异(P>0.05)。结论:中药降糖明目汤具有一定的抑制NF-κBp65的表达,降低血清抵抗素浓度的作用。Objective：To observe the effect of jiangtangmingmu formula to BDR model Rabbits＇Resistin and NF-κB p65. Methods：BDR model Rabbits were randomly divided into jiangtang -mingmu formula group,western medicine Doxium group and model group,detecting serum Resistin,the expression of NF-κB p65 in pancreatic gland,and compared with normal group＇s. Results：The density of serum Resistin of model group obviously increases and there is obviously significance compared with the other three groups（ P 0. 01） ,but there no significance among control group and western medicine group,normal group（ P 0. 05）. there is high expression of NF-κB p65 in pancreatic gland of model group,and statistic significance compared with control group and normal group（ P 0. 01） ,but no significance with western medicine group（ P 0. 05）. there is statistic significance between control group and western medicine group（ P 0. 05） ,and no significance with between control group and normal group（ P 0. 05）. Conclusion：Jiangtang-mingmu formula can inhibit expression of NF-κB p65 and lower down the density of serum Resistin.

关 键 词：降糖明目汤 背景期糖尿病视网膜病变 抵抗素 NF-ΚB 

分 类 号：R285.5[医药卫生—中药学]