复合材料PAA-PNIPA/APS-SBA-15的制备及其药物缓释性能  

Preparation of mesoporous composite PAA-PNIPA/APS-SBA-15 and its application in drug delivery

作　　者：周志平[1] 孔祥涛[1] 盛维琛[1] 朱申敏[2] 

机构地区：[1]江苏大学材料科学与工程学院,江苏镇江212013 [2]上海交通大学金属基复合材料国家重点实验室,上海200240

出　　处：《江苏大学学报（自然科学版）》2010年第5期544-548,共5页Journal of Jiangsu University：Natural Science Edition

基　　金：国家自然科学基金资助项目(20774038);上海交通大学金属基复合材料国家重点实验室开放课题项目

摘　　要：采用功能性聚合物对氨基改性的介孔氧化硅SBA-15进行负载改性,将丙烯酸和N-异丙基丙烯酰胺引入孔道内,经自由基聚合反应制备了功能性介孔纳米材料PAA-PNIPA/APS-SBA-15.分别用X射线衍射仪、透射电镜、氮气吸附脱附技术、傅立叶红外光谱等分析手段对该材料的结构和形貌进行了表征,并进行了药物释放试验.结果表明,聚合物负载在介孔材料的孔道中实现了双重复合改性,复合后介孔材料的孔体积为0.313 1 cm3/g,比表面积为171.4 m2/g,该复合材料仍然保持了介孔材料的有序结构,具有药物缓释特性,可同时具有pH敏感性和温度敏感性.The monomers of acrylic acid and N-isopropylacrylamide were introduced into the channels of amino-modified SBA-15 and the functional mesoporous composite,PAA-PNIPA/APS-SBA-15,was prepared by free radical polymerization.The structure of the composite was characterized by Fourier-transform infrared spectroscopy,X-ray diffraction,transmission electron microscopy,and N2 adsorption-desorption,respectively.The drug release behavior of the composite was investigated.The results show that the composite remains ordered pore structure,the polymers are present inside the channels,and the nanocomposite keeps the pore volume of 0.313 1 cm^3/g and the specific surface area of 171.4 m^2/g.It shows the property of drug sustained-release and both thermo-sensitivity and pH-sensitivity in the simulated solutions.

关 键 词：介孔氧化硅SBA-15 介孔复合材料 制备 改性 药物释放 

分 类 号：TB34[一般工业技术—材料科学与工程]