辣椒碱凝胶膏剂基质的处方优化  

Optimization of Matrix Formulation of Capsaicin Cataplasm

作　　者：彭新生[1,2,3] 缪旭[1,2] 苏健芬[1,2] 卢浩扬[1,2] 吴传斌[1,2] 

机构地区：[1]中山大学药学院,广东广州510006 [2]广东省高校创新药物制剂工程技术研究中心,广东广州510006 [3]广东医学院药学院,广东东莞523808

出　　处：《今日药学》2010年第9期12-14,18,共4页Pharmacy Today

基　　金：广东省高校创新药物制剂工程技术研究中心建设项目(编号:GCZX-A0801)

摘　　要：目的优化辣椒碱凝胶膏剂基质处方及制备工艺。方法以初黏力作为考察指标,采用单因素试验设计法及正交试验设计法优化聚丙烯酸钠、羧甲基纤维素钠、卡波姆940、明胶、三氯化铝、三乙醇胺的配比。结果聚丙烯酸钠、羧甲基纤维素钠、卡波姆940、明胶混合后用甘油溶液浸泡过夜,加入填充剂硅胶G,基质可充分混匀,易于涂布。优化的基质处方:聚丙烯酸钠1.2 g、CMC-Na.0.5 g、卡波姆0.3 g、明胶3.0 g、18.75%甘油(v/v)40 ml、20%三氯化铝0.4 ml、三乙醇胺4 ml,在60℃涂布。结论该工艺条件简便易于产业化,按优化后的基质处方制备的辣椒碱凝胶膏剂基质具有良好的延展性,外观平整光滑,符合药用标准。Objective To optimize the matrix formulation of capsaicin cataplasm.Methods A single-factor experiment and orthogonal design were applied to optimize the optimum ratio of sodium polyacrylate,sodium carboxymethyl cellulose（CMC-Na）,carbomer 940,gelatin,aluminium trichloride,triethanolamine with the index of initial viscosity.Results CMC-Na,carbomer 940 and gelatin were mingled together and immersed in glycerin solution overnight,then silicon gel G was added,the matrixes could be mixed and spreaded easily.The optimal formulation of capsaicin cataplasm was： sodium polyacrylate 1.2 g,CMC-Na 0.5 g,carbomer 940 0.3 g,gelatin 3.0 g,glycerol solution（18.75%,v/v） 40 ml,aluminium trichloride solution（20%）0.4 ml,triethanolamine 4 ml,the temperature of the preparation was 60℃.Conclusion The preparation technique was feasible and served as rationale for the industrialization of the capsaicin cataplasm.Cataplasm showed moderate viscosity with good spreadability.The characteristic was in line with the medicinal standard.

关 键 词：凝胶膏剂 正交设计法 处方优化 

分 类 号：R971.2[医药卫生—药品]