磁共振波谱成像对艾滋病患者认知障碍的诊断价值  

MR spectroscopy for evaluation of cognitive impairment in AIDS patients

作　　者：王玲[1] 史大鹏[1] 韩雄[2] 赵清霞 闫斌[4] 李宏军[5] 

机构地区：[1]河南省人民医院放射科,450003 [2]河南省人民医院神经内科,450003 [3]河南省传染病医院,450061 [4]解放军信息工程大学,450001 [5]首都医科大学附属北京佑安医院放射科,100069

出　　处：《磁共振成像》2010年第5期349-352,共4页Chinese Journal of Magnetic Resonance Imaging

摘　　要：目的探讨多体素1H-MRS方法在AIDS患者认知障碍中的诊断价值。方法利用3.0T磁共振对21例有认知障碍的AIDS患者(ADC),19例无认知障碍AIDS患者(NAS)及20例正常志愿者(SN)进行MR波谱分析,分别测量额叶白质区、基底节区和后顶叶正中灰质区NAA、Cho、MI、Cr的峰下面积及其与Cr比值,比较每两组间代谢率的差异。结果与正常对照组比较,额叶白质区:ADC组NAA/Cr明显降低(1.2502)、Cho/Cr升高(1.2028),NAS组NAA/Cr降低(1.5334);基底节区:ADC组和NAS组NAA/Cr均降低(分别为1.2625和1.5278),ADC组Cho/Cr明显升高(1.1631);后顶叶正中灰质区:ADC组和NAS组NAA/Cr、Cho/Cr和MI/Cr较对照组有变化,但差别无统计学意义。结论 AIDS患者脑代谢物变化与认知障碍有无及程度有一定关系,MRS可作为反映AIDS神经损伤有价值的检查方法。Objective： To assess the value of MR spectroscopy in the diagnosis of cognitive impairment in AIDS patients. Materials and Methods： 3.0 T MR was used to measured NAA, Cho, MI and Cr in the frontal white matter, basal ganglia and parietal cortex of 21 AIDS patients with dementia complex （ADC）, 19 neuroasymptomatic AIDS patients （NAS） and 20 seronegative controls （SN）, respectively; and then compared the difference of metabolic rate between AIDS patients and SN controls. Results： NAA/Cr （1.2502） was significantly decreased and Cho/Cr （1.2028） was increased in the frontal white matter in ADC group, while NAA/ Cr （1.5334） was reduced in NAS group compared with that in SN group, NAA/Cr in the basal ganglia was decreased in both ADC and NAS groups （1.2625 and 1.5278, respectively）, Cho/Cr （1.1631） was obviously increased in ADC group. Although NAA/Cr, Cho/Cr and MI/Cr in the parietal cortex had some degree of change in both ADC and NAS groups compared with SN group, but the difference has not statistically significant. Conclusion： The brain metabolite changes of AIDS patients are correlated with cognitive impairment. MR spectroscopy can be used as a valuable method to assess cognitive impairment in AIDS patients.

关 键 词：获得性免疫缺陷综合征 脑代谢物 认知障碍 磁共振波谱 

分 类 号：R512.91[医药卫生—内科学] R445.2[医药卫生—临床医学]