香加皮化学成分的研究  

Chemical constituents of the root barks of Periploca sepium

作　　者：李金楠[1] 赵丽迎[1] 于静[1] 高缨[1] 邓雁如[1] 

机构地区：[1]天津中医药大学天津市中药化学与分析重点实验室,天津300193

出　　处：《中成药》2010年第9期1552-1556,共5页Chinese Traditional Patent Medicine

基　　金：国家科技支撑计划药品安全关键技术研究(2006BAI14B00)--常见与重要药品安全标准研究(2006BAI14B01)

摘　　要：目的:研究香加皮的化学成分。方法:采用硅胶、ODS柱色谱等方法分离纯化,利用理化性质及波谱方法鉴定化学成分的结构。结果:分离并鉴定了11个化合物,分别为异香草醛(Ⅰ),4-甲氧基水杨酸(Ⅱ),4-甲氧基水杨醛(Ⅲ),咖啡酸乙酯(Ⅳ),东莨菪内酯(Ⅴ),5,5′-二甲氧基落叶松脂醇-4′-O-β-D-吡喃葡萄糖苷(tortosideB)(Ⅵ),periplocosideL(Ⅶ),Δ5-孕甾烯-3β,20(S)-二醇(Ⅷ),Δ5-孕甾烯-3β,20(S)-二醇-20-O-β-D-吡喃葡萄糖-3-O-β-D-吡喃葡萄糖苷(Ⅸ),Δ5-孕甾烯-3β,20(S)-二醇-20-O-β-D-吡喃葡萄糖基(1→6)-β-D-吡喃葡萄糖苷(Ⅹ),Δ5-孕甾烯-3β,20(S)-二醇-3-O-[2-O-乙酰基-β-D-吡喃洋地黄糖基(1→4)-β-D-吡喃加拿大麻糖]-20-O-β-D-吡喃葡萄糖基(1→6)-β-D-吡喃葡萄糖基(1→2)-β-D-吡喃洋地黄糖苷(Ⅺ)。结论:其中化合物Ⅳ,Ⅵ,Ⅸ和Ⅹ为首次从该种药材中得到。AIM： To study the chemical constituents of the root barks of Periploca sepium. METHODS： The chemical constituents were isolated by column chromatography on silical gel,and ODS. Their structures were elucidated on the basis of spectral analysis and physico-chemical properties. RESULTS： Eleven compounds were isolated from the root barks of Periploca sepium and the structures of them were identified as isovanillin（Ⅰ）,4-methox-ysalicylic acid（Ⅱ）,4-methoxysalicylaldehyde（Ⅲ）,ethyl caffeate（Ⅳ）,scopoletin（Ⅴ）,5,5′-dimethoxylaricires-inol-4′-O-β-D-glucopyranoside （tortoside B）（Ⅵ）,periplocoside L（Ⅶ）,5-pregene-3β,20（S）-diol（Ⅷ）,5-pre-gene-3β,20（S）-diol-20-O-β-D-glucopyranoside-3-O-β-D-glucopyranoside（Ⅸ）,5-pregene-3β,20（S）-diol-20-O-β-D-glucopyranosyl（1→6）-β-D-glucopyranoside（Ⅹ）,5-pregene-3β,20（S）-diol-3-O-[2-O-acetyl-β-D-digitalopy-ranosyl（1 →4）-β-D-cymaropyranoside]-20-O-β-D-glucopyranosyl（1 →6）-β-D-glucopyranosyl（1 →2）-β-D-digita-lopyranoside（Ⅺ）,respectively. CONCLUSION： Compounds Ⅳ,Ⅵ,Ⅸ and Ⅹ were isolated from the root barks of Periploca sepium for the first time.

关 键 词：香加皮 化学成分 5 5′-二甲氧基落叶松脂醇-4′-O-β-D-吡喃葡萄糖苷 

分 类 号：R284.1[医药卫生—中药学]